The article by our colleague Niels Connel titled: "NAD+-Precursor Supplementation With L-Tryptophan, Nicotinic Acid, and Nicotinamide Does Not Affect Mitochondrial Function or Skeletal Muscle Function in Physically Compromised Older Adults" has been published in the Journal of Nutrition. Read the full article here: https://doi.org/10.1093/jn/nxab193 Read the abstract below. BACKGROUND: Boos...

The first article of Anna Veelen has now been published in Molecular Metabolism. This review titled: "Type 2 diabetes subgroups and potential medication strategies in relation to effects on insulin resistance and beta-cell function: A step toward personalised diabetes treatment?"  The full review can be found here: https://doi.org/10.1016/j.molmet.2020.101158 Read the abstract below. BACK...

Together with our colleagues of the department of Human Biology, our colleagues Marlies de Ligt and Matthijs Hesselink published the article "The angiotensin II type 1 receptor blocker valsartan in the battle against COVID-19" in the journal Obesity (Silver Spring).  The full article is available here: https://doi.org/10.1002/oby.23221 Read the abstract below. OBJECTIVE: Severe acute resp...

In collaboration with our colleagues in at University of Amsterdam, Jan-Frieder Harmsen has published a new article in  the FASEB Journal and demonstrated that controlled shortterm circadian misalignment distributed the skeletal muscle lipidome, whereas lipid droplet morphology remained unalterd. The full manuscript with the title "Circadian misalignment disturbs the skeletal muscle lipidome in...

Published in Diabetes Care by our colleague Yvo op den Kamp and now available online ahead of print is the article called: "Effects of the SGLT2 Inhibitor Dapagliflozin on Energy Metabolism in Patients With Type 2 Diabetes: A Randomized, Double-Blind Crossover Trial". Full article can be found here: https://doi.org/10.2337/dc20-2887 Read the abstract below. OBJECTIVE: SGTL2 inhibitors inc...

The article by Emmani Nascimento is now available in The Journal of Clinical Endocrinology and Metabolism with the title: "Nicotinamide Riboside Enhances In Vitro Beta-adrenergic Brown Adipose Tissue Activity in Humans". NR stimulates in vitro human BAT but not in vivo BAT in humans. Our research demonstrates the need for further translational research to better understand the differences in NAD+ ...

Scientists from the Netherlands and Canada are to investigate whether lifestyle changes can help to restore the 24-hour rhythm of people at a high risk of developing type 2 diabetes. The Dutch researchers, including Professor Patrick Schrauwen of Maastricht University, have already concluded that people with a predisposition to type 2 diabetes have a disrupted circadian rhythm, or biological cl...

A recent manuscript published in Nature Communication by our team show that mild cold acclimation for 10 days in patients with type 2 diabetes in which observable, overt shivering was prevented, does not result in improved insulin sensitivity. The full article can be found here: https://doi.org/10.1038/s41467-021-21813-0 ABSTRACT Mild cold acclimation for 10 days has been previously shown to...

An interesting read by our colleague Sten van Beek on "Prolonged β 2-adrenergic agonist treatment improves glucose homeostasis in diet-induced obese UCP1 -/- mice". This manuscript is published in the American Journal of Physiology Metabolism & Endocrinology and full text can be found online: https://doi.org/10.1152/ajpendo.00324.2020  Read the abstract below: Prolonged supplementation...

This year published in Nature Metabolism is an article by our colleague Niels Connell titled "No evidence for brown adipose tissue activation after creatine supplementation in adult vegetarians." The full article can be found here: https://doi.org/10.1038/s42255-020-00332-0 Read the abstract below. Creatine availability in adipose tissue has been shown to have profound effects on thermoge...