New article by Jan-Frieder Harmsen on circadian misalignment and skeletal muscle lipidome

In collaboration with our colleagues in at University of Amsterdam, Jan-Frieder Harmsen has published a new article in  the FASEB Journal and demonstrated that controlled shortterm circadian misalignment distributed the skeletal muscle lipidome, whereas lipid droplet morphology remained unalterd. The full manuscript with the title "Circadian misalignment disturbs the skeletal muscle lipidome in healthy young men" can be found here: https://doi.org/10.1096/fj.202100143R Read the abstract belo...
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Publication on DAPAMAAST trail

Published in Diabetes Care by our colleague Yvo op den Kamp and now available online ahead of print is the article called: "Effects of the SGLT2 Inhibitor Dapagliflozin on Energy Metabolism in Patients With Type 2 Diabetes: A Randomized, Double-Blind Crossover Trial". Full article can be found here: https://doi.org/10.2337/dc20-2887 Read the abstract below. OBJECTIVE: SGTL2 inhibitors increase urinary glucose excretion and have beneficial effects on cardiovascular and renal outcomes. Th...
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Long-term research on the effects of lifestyle on the biological clock

Scientists from the Netherlands and Canada are to investigate whether lifestyle changes can help to restore the 24-hour rhythm of people at a high risk of developing type 2 diabetes. The Dutch researchers, including Professor Patrick Schrauwen of Maastricht University, have already concluded that people with a predisposition to type 2 diabetes have a disrupted circadian rhythm, or biological clock. People who do shift work, for example, are also known to be more likely to develop type 2 diabe...
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Publication in Nature Communication by our team members

A recent manuscript published in Nature Communication by our team show that mild cold acclimation for 10 days in patients with type 2 diabetes in which observable, overt shivering was prevented, does not result in improved insulin sensitivity. The full article can be found here: https://doi.org/10.1038/s41467-021-21813-0 ABSTRACT Mild cold acclimation for 10 days has been previously shown to markedly improve insulin sensitivity in patients with type 2 diabetes. Here we show in a single-arm...
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Publication by Sten van Beek in the American Journal of Physiology Metabolism & Endocrinology

An interesting read by our colleague Sten van Beek on "Prolonged β 2-adrenergic agonist treatment improves glucose homeostasis in diet-induced obese UCP1 -/- mice". This manuscript is published in the American Journal of Physiology Metabolism & Endocrinology and full text can be found online: https://doi.org/10.1152/ajpendo.00324.2020  Read the abstract below: Prolonged supplementation with the β2-agonist clenbuterol improves glucose homeostasis in diabetic rodents, likely via β2-adr...
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Review published ahead of print by Charlotte Andriessen

The newest review by Charlotte Andriessen has been published (ahead of print) in the International Journal of Obesity with the title: "The importance of 24-h metabolism in obesity-related metabolic disorders: opportunities for timed interventions". The  review can be found online: https://doi.org/10.1038/s41366-020-00719-9 Read the abstract below: Various metabolic processes in the body oscillate throughout the natural day, driven by a biological clock. Circadian rhythms are also influence...
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New review by Kay Roumans

Last week, a new article of Kay Roumans was published online ahead of print: "Liver fat storage pathways: methodologies and dietary effects". The article in Current Opinion in Lipodology can be found here: https://doi.org/10.1097/mol.0000000000000720  Read the abstract below: PURPOSE OF REVIEW: Nonalcoholic fatty liver is the result of an imbalance between lipid storage [from meal, de novo lipogenesis (DNL) and fatty acid (FA) uptake] and disposal (oxidation and VLDL output). Knowledge on ...
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Article by Anne Gemmink

Our colleague Anne Gemmink, together with other members of our research group, published an article titled: "Decoration of myocellular lipid droplets with perilipins as a marker for in vivo lipid droplet dynamics: A super-resolution microscopy study in trained athletes and insulin resistant individuals". This article is published in Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids and the full article can be found here: https://doi.org/10.1016/j.bbalip.2020.158852 Read the...
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New article by Froukje Vanweert

The very first article of Froukje Vanweert as first author has been published titled "Elevated plasma branched-chain amino acid levels correlate with type 2 diabetes-related metabolic disturbances". The full article can be found online: https://doi.org/10.1210/clinem/dgaa751 Read the abstract below: CONTEXT: Patients with type 2 diabetes (T2DM) have elevated plasma branched-chain amino acid levels (BCAA). The underlying cause is however not known. Low mitochondrial oxidation of BCAA could ...
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