The article from our former colleague Vera de Wit is now online available and will be published in Obesity with the following title: "The tissue-specific metabolic effects of the PPARα agonist ciprofibrate in insulin-resistant male individuals: a double-blind, randomized, placebo-controlled crossover study”. The full article can be found here: https://doi.org/10.1002/oby.23874 Read the abstract below. Abstract Advances in the development of noninvasive imaging techniques have spurred in...

The article from our former colleague Vera de Wit is now online available and will be published in Obesity with the following title: "The tissue-specific metabolic effects of the PPARα agonist ciprofibrate in insulin-resistant male individuals: a double-blind, randomized, placebo-controlled crossover study”. The full article can be found here: https://doi.org/10.1002/oby.23874 Read the abstract below. Abstract Objective: Insulin resistance is characterized by ectopic fat accumulation le...

The article from our former colleague Vera de Wit is now online available and will be published in Scientific Reports with the following title: PCr/ATP ratios and mitochondrial function in the heart. A comparative study in humans”. The full article can be found here: https://doi.org/10.1038/s41598-023-35041-7 Read the abstract below. Abstract Cardiac energy status, measured as phosphocreatine (PCr)/adenosine triphosphate (ATP) ratio with 31P-Magnetic Resonance Spectroscopy (31P-M...

The article from our colleague Anne Gemmink is now online available and will be published in Molecular metabolism with the following title: “Twenty-four hour rhythmicity in mitochondrial network connectivity and mitochondrial respiration; a study in human skeletal muscle biopsies of young lean and older individuals with obesity”. The full article can be found here: https://doi.org/10.1016/j.molmet.2023.101727 Read the abstract below. Abstract Mitochondrial network dynamics may play role i...

The article from our colleagues Jeremy Basset-Sagarminaga and Kay Roumans isnow online available and will be published in Nutrients withthe following title: “Replacing Foods with a High-Glycemic Index and High inSaturated Fat by Alternatives with a Low Glycemic Index and Low Saturated FatReduces Hepatic Fat, Even in Isocaloric and Macronutrient Matched Conditions”. The full article can be found here: https://doi.org/10.3390/nu15030735 Read the abstract below. Abstract Backgrou...

The article from our colleagues Kay Roumans, Anna Veelen and Charlotte Andriessen is now online available and will be published in Obesity with the following title: “A prolonged fast improves overnight substrate oxidation without modulating hepatic glycogen in adults with and without nonalcoholic fatty liver. A randomized crossover trial. The full article can be found here: https://doi.org/10.1002/oby.23676 Read the abstract below. Abstract Objective: Increasing overnight fasting time se...

The review from our colleague Dzhansel Hashim and former colleague Sten van Beek is now online available and will be published in  the International Journal of Obesity with the following title: “Physiological and molecular mechanisms of could-induced improvements in glucose homeostasis in humans beyond brown adipose tissue”. The full article can be found here: https://doi.org/10.1038/s41366-023-01270-z Read the abstract below. Abstract Exposure to low ambient temperatures h...

The article from our colleague Sten van Beek is now online available and will be published in Nature Communications with the following title: “Effect of β2-agonist treatment on insulin-stimulated peripheral glucose disposal in healthy men in a randomised placebo-controlled trial”. The full article can be found here: https://doi.org/10.1038/s41467-023-35798-5 Read the abstract below. Abstract β2-agonist treatment improves skeletal muscle glucose uptake and whole-body glucose homeosta...

The article from our colleague Anna Veelen is now online available and will be published in Metabolism with the following title: “Effects of the sodium-glucose cotransporter 2 inhibitor dapagliflozin on substrate metabolism in prediabetic insulin resistant individuals: A randomized, double-blind crossover trial”. The full article can be found here: https://doi.org/10.1016/j.metabol.2022.155396 Read the abstract below. Abstract Aims/hypothesis: Sodium-glucose cotransporter 2 inh...