Long-term research on the effects of lifestyle on the biological clock

Scientists from the Netherlands and Canada are to investigate whether lifestyle changes can help to restore the 24-hour rhythm of people at a high risk of developing type 2 diabetes. The Dutch researchers, including Professor Patrick Schrauwen of Maastricht University, have already concluded that people with a predisposition to type 2 diabetes have a disrupted circadian rhythm, or biological clock. People who do shift work, for example, are also known to be more likely to develop type 2 diabe...
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Publication in Nature Communication by our team members

A recent manuscript published in Nature Communication by our team show that mild cold acclimation for 10 days in patients with type 2 diabetes in which observable, overt shivering was prevented, does not result in improved insulin sensitivity. The full article can be found here: https://doi.org/10.1038/s41467-021-21813-0 ABSTRACT Mild cold acclimation for 10 days has been previously shown to markedly improve insulin sensitivity in patients with type 2 diabetes. Here we show in a single-arm...
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Publication by Sten van Beek in the American Journal of Physiology Metabolism & Endocrinology

An interesting read by our colleague Sten van Beek on "Prolonged β 2-adrenergic agonist treatment improves glucose homeostasis in diet-induced obese UCP1 -/- mice". This manuscript is published in the American Journal of Physiology Metabolism & Endocrinology and full text can be found online: https://doi.org/10.1152/ajpendo.00324.2020  Read the abstract below: Prolonged supplementation with the β2-agonist clenbuterol improves glucose homeostasis in diabetic rodents, likely via β2-adr...
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Review published ahead of print by Charlotte Andriessen

The newest review by Charlotte Andriessen has been published (ahead of print) in the International Journal of Obesity with the title: "The importance of 24-h metabolism in obesity-related metabolic disorders: opportunities for timed interventions". The  review can be found online: https://doi.org/10.1038/s41366-020-00719-9 Read the abstract below: Various metabolic processes in the body oscillate throughout the natural day, driven by a biological clock. Circadian rhythms are also influence...
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New review by Kay Roumans

Last week, a new article of Kay Roumans was published online ahead of print: "Liver fat storage pathways: methodologies and dietary effects". The article in Current Opinion in Lipodology can be found here: https://doi.org/10.1097/mol.0000000000000720  Read the abstract below: PURPOSE OF REVIEW: Nonalcoholic fatty liver is the result of an imbalance between lipid storage [from meal, de novo lipogenesis (DNL) and fatty acid (FA) uptake] and disposal (oxidation and VLDL output). Knowledge on ...
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Article by Anne Gemmink

Our colleague Anne Gemmink, together with other members of our research group, published an article titled: "Decoration of myocellular lipid droplets with perilipins as a marker for in vivo lipid droplet dynamics: A super-resolution microscopy study in trained athletes and insulin resistant individuals". This article is published in Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids and the full article can be found here: https://doi.org/10.1016/j.bbalip.2020.158852 Read the...
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New article by Froukje Vanweert

The very first article of Froukje Vanweert as first author has been published titled "Elevated plasma branched-chain amino acid levels correlate with type 2 diabetes-related metabolic disturbances". The full article can be found online: https://doi.org/10.1210/clinem/dgaa751 Read the abstract below: CONTEXT: Patients with type 2 diabetes (T2DM) have elevated plasma branched-chain amino acid levels (BCAA). The underlying cause is however not known. Low mitochondrial oxidation of BCAA could ...
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EASD – Presentation by Yvo op den Kamp

Last week during the virtual EASD meeting, Yvo op den Kamp presented his work on the effects of 5 weeks of treatment with dapagliflozin, a SGLT2 inhibitor, on energy metabolism in patients with type 2 diabetes. The key messages of this presentation were that dapagliflozin treatment vs placebo resulted in: Unchanged 24-h energy expenditure, while 24-h fatty acid oxidation increased, inducing a negative fat balance Improved metabolic flexibility as indicated from a larger difference in day...
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New article online by Yvonne Bruls

Now online available is the most recent article by Yvonne Bruls and colleagues titled " L-carnitine infusion does not alleviate lipid-induced insulin resistance and metabolic inflexibility". The full article can be found online: https://doi.org/10.1371/journal.pone.0239506 Read the abstract below: BACKGROUND: Low carnitine status may underlie the development of insulin resistance and metabolic inflexibility. Intravenous lipid infusion elevates plasma free fatty acid (FFA) concentration and...
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