New review on changes in cardiac metabolism in prediabetes

The article from our colleague Vera de Wit is now online available and will be published in Biomolecules with the following title: “Changes in Cardiac Metabolism in Prediabetes". The full article can be found here: https://doi.org/10.3390/biom11111680 Read the abstract below: In type 2 diabetes mellitus (T2DM), there is an increased prevalence of cardiovascular disease (CVD), even when corrected for atherosclerosis and other CVD risk factors. Diastolic dysfunction is one of the early ...
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New article on plasma branched-chain amino acids and Type 2 Diabetes related metabolic disturbances

The article from our colleague Froukje Vanweert is now online available and will be published in the Journal of Clinical Endocrinology & Metabolism with the following title: "Elevated Plasma Branched-Chain Amino Acid Levels Correlate With Type 2 Diabetes-Related Metabolic Disturbances". The full article can be found here: https://pubmed.ncbi.nlm.nih.gov/33079174/ Read the abstract below. Context: Patients with type 2 diabetes mellitus (T2DM) have elevated plasma branched-chain ami...
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Publication by Carlijn Remie on sitting less

The article by Carlijn Remie is now available in Diabetologia with the title: "Sitting less elicits metabolic responses similar to exercise and enhances insulin sensitivity in postmenopausal women". Read the full article here: https://pubmed.ncbi.nlm.nih.gov/33079174/ Read the abstract below. Aims/hypothesis: In our current society sedentary behaviour predominates in most people and is associated with the risk of developing type 2 diabetes. It has been suggested that replacing sitting t...
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New review on skeletal muscle mitochondrial network dynamics

Published in Trends in Molecular Medicine this August, is the review by our colleagues on skeletal muscle mitochondrial network dynamics in metabolic disorders and aging. The full article can be found here: https://doi.org/10.1016/j.molmed.2021.07.013 Read the abstract below. With global demographics trending towards an aging population, the numbers of individuals with an age-associated loss of independence is increasing. A key contributing factor is loss of skeletal muscle mitochondrial, ...
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Resveratrol supplementation reduces ACE2 expression

The article by our colleagues titled "Resveratrol supplementation reduces ACE2 expresssion in human adipose tissue" which will be published in Adipocyte and is in collaboration with the department of Human Biology. Full text can be found here: https://doi.org/10.1080/21623945.2021.1965315 Read the abstract below. Angiotensin converting enzyme-2 (ACE2) is the cell-surface receptor enabling cellular entry of SARS-CoV-2. ACE2 is highly expressed in adipose tissue (AT), rendering AT a poten...
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Article published August 16 on post-exercise changes in myocellular lipid droplets

This summer, our colleagues published an article in the American Journal of Physiology-Endocrinology and Metabolism with the title: "Post-exercise changes in myocellular lipid droplet characteristics of young lean individuals are affected by circulatory non-esterified fatty acids". Acute exercise affects intramyocellular lipid (IMCL) storage during exercise and recorvery, particularly in type I muscle fibers, in the subsarcolemmal region and in the presence of PLIN5. Moreover, the effects of exe...
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Article on the link between mitochondrial function and age-associated deterioration of skeletal muscle

Published in Nature Communications by our colleagues is a new article titled: "Impact of aging and exercise on skeletal muscle mitochondrial capacity, energy metabolism, and physical function", examing to what extent physical activity contributes to the decline in mitochondrial function and muscle health during aging. The full article can be found here: https://doi.org/10.1038/s41467-021-24956-2 Read the abstract below. The relationship between the age-associated decline in mitochondria...
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Day-night rhythm disturbance

Published by our group in Molecular Metabolism was the article titled: "Day-night rhythm of skeletal muscle metabolism is disturbed in older, metabolically compromised individuals". It shows that mitochondrial oxidative capacity does not show a day-night rhythm in older, overweight participants with impaired glucose tolerance and insulin sensitivity. The full article can be found here: https://doi.org/10.1016/j.molmet.2020.101050 Read the abstract below. OBJECTIVE: Skeletal muscle mitoc...
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New article on exercise and plasma branched-chain amino acids and intrahepatic lipids

The article from our colleague Frouke Vanweert is now online available and will be publische in the International Journal of Obesity with the following title: "The effect of physical activity level and exercise training on the association between plasma branched-chain amino acids and intrahepatic lipid content in participants with obesity". The full article can be found here: https://doi.org/10.1038/s41366-021-00815-4 Read the abstract below. AIMS: To evaluate whether the association be...
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Article on mitochondrial function and NAD+ precursor supplementation

The article by our colleague Niels Connel titled: "NAD+-Precursor Supplementation With L-Tryptophan, Nicotinic Acid, and Nicotinamide Does Not Affect Mitochondrial Function or Skeletal Muscle Function in Physically Compromised Older Adults" has been published in the Journal of Nutrition. Read the full article here: https://doi.org/10.1093/jn/nxab193 Read the abstract below. BACKGROUND: Boosting NAD+ via supplementation with niacin equivalents has been proposed as a potential modality capa...
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