New article by Esther Phielix

Esther Phielix has published a new article titled "Athletes feature greater rates of muscle glucose transport and glycogen synthesis during lipid infusion" in the Journal of Clinical Investigation Insight. The full article can be found on https://doi.org/10.1172/jci.insight.127928  Read the abstract below. BACKGROUND: Insulin resistance results from impaired skeletal muscle glucose transport/phosphorylation, linked to augmented lipid availability. Despite greater intramuscular lipids, athlet...
More

EFSD grant for Jan-Frieder Harmsen

Congratulations to our colleague Jan-Frieder Harmsen who secured a grant of the European Foundation for the Study of Diabetes (EFSD)! The project will focus on circadian rhythm and will build further on the previous day-night rhythm studies performed by our group. These studies revealed that pre-diabetes volunteers lack day-night rhythmicity in mitochondrial function and in 24h substrate metabolism in contrast to young healthy individuals. Moreover, the endogenous molecular clock in skeletal mus...
More

New start in 2020

Today, most of our colleagues started to work again after well deserved holidays. Unfortunately, Maastricht University (UM) was hit by a serious cyberattack before Christmas. Despite a number of limitations, many activities could continue after the Christmas break without major problems. Some of our colleagues had to forego their Christmas break and (literally) work day and night. Others have sacrificed part of their vacation voluntarily to help. A big word of thanks to everyone for all their su...
More

NVDO – Assessment of metabolic flexibility upon insulin stimulation and incremental submaximal exercise

During the NVDO meeting, Maaike Bergman presented her work on the assessment of metabolic flexibility upon insulin stimulation and incremental submaximal exercise. Metabolic flexibility is defined as the adaptability of substrate oxidation to substrate availability, which is commonly measured as the change in respiratory exchange ratio. In obese, metabolically compromised subjects, metabolic flexibility is disrupted, expressed by a blunted change from fat to glucose oxidation upon insulin sti...
More

NVDO – Slow activation of oxidative metabolism at the onset of exercise is associated with low CRAT protein activity

Rodrigo Mancilla presented during the NVDO meeting about the slow activation of oxidative metabolism at the onset of exercise and how this is associated with low CRAT protein activity. Metabolically compromised subjects, such as obese and type 2 diabetic patients, exhibit a strong reliance on oxygen-independent pathways (for example PCr hydrolysis) to resynthesize ATP when exercise starts. This phenomenon seems to be due to deficiency of intramyocellular Acetyl Coa availability, causing a del...
More

NVDO – Sedentary time replaced by standing and walking is as effective in improving peripheral insulin sensitivity compared to exercise training

Carlijn Remie presented on behalf of Kay Roumans about how replacing sedentary time by standing and walking is as effective in improving peripheral insulin sensitivity compared to exercise training. Replacing sitting time with several hours of walking and standing does improve peripheral insulin sensitivity to the same extent as replacing sitting time by 1 hour of vigorous exercise.
More

NVDO – Effects of nicotinamide riboside on human metabolism

During the NVDO meeting of 28 and 29 November 2019, Carlijn Remie presented her results on the effects of nicotinamide riboside on human metabolism. NR supplementation of 1000 mg/day for six weeks did not improve markers of metabolic health in overweight/obese men and women, except for minor changes in body composition and skeletal muscle acetylcarnitine concentrations.
More

NVDO – Absence of a day-night rhythm in skeletal muscle metabolism of insulin resistant individuals

During the NVDO meeting, Ciarán presented about the absence of a day-night rhythm in skeletal muscle metabolism of insulin-resistant individuals. The key messages of his presentation where that: Insulin resistant individuals have a marked absence of day-night variation in skeletal muscle mitochondrial function Day-Night rhythm of peripheral clock gene expression is disrupted in individuals with insulin resistance. Insulin resistant individuals display metabolic inflexibility over the ...
More