New article on skeletal muscle mitochondrial inertia online

The article from our colleague Rodrigo Mancilla is now online available and will be published in  JCI Insight with the following title: “Skeletal muscle mitochondrial inertia associates with carnitine acetyltransferase activity and physical function in humans”. The full article can be found here: https://doi.org/10.1172/jci.insight.163855 Read the abstract below. Background: At the onset of exercise, the speed at which PCr decreases towards a new steady state (PCr on-kinetics), refl...
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New article on the effects of SGLT2 inhibitor dapagliflozin

The article from our colleagues Anne Gemmink and Yvo op den Kamp is now online available and will be published in  Molecular metabolism with the following title: “Effects of SGLT2 inhibitor dapagliflozin in patients with type 2 diabetes on skeletal muscle cellular metabolism”. The full article can be found here: https://doi.org/10.1016/j.molmet.2022.101620   Read the abstract below. Objective: SGLT2 inhibitors increase urinary glucose excretion and have beneficial effects on c...
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New review on the role of branched-chain amino acids

The review from our colleague Froukje Vanweert is now online available and will be published in  Nutrition & Diabetes with the following title: “Role of brached-chain amino acid metabolism in the pathogenesis of obesity and type 2 diabetes-related metabolic disturbances BCCA metabolism in type 2 diabetes”. The full article can be found here: https://doi.org/10.1038/s41387-022-00213-3   Read the abstract below. Branched-chain amino acid (BCAA) catabolism has been considered to ...
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Publication by Charlotte Andriessen on time-restricted eating

The article from our colleague Charlotte Andriessen is now online available and will be published in  Diabetologia with the following title: “Three weeks of time-restricted eating improves glucose homeostasis in adults with type 2 diabetes but does not improve insulin sensitivity: a randomised crossover trial”. The full article can be found here: https://doi.org/10.1007/s00125-022-05752-z   Read the abstract below. Aims/hypothesis Time-restricted eating (TRE) is suggested to impr...
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New review online on the novel insights in intestinal and hepatic fructose metabolism

The article from our colleague Evi Koene is now online available and will be published in Current opinion in clinical nutrition and metabolic care with the following title: “Novel insights in intestinal and hepatic fructose metabolism: from mice to men". The full article can be found here: https://doi.org/10.3390/biom11111680 Read the abstract below: Purpose of review: The rise in fructose consumption in parallel with the current epidemic of obesity and related cardiometabolic disease...
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Kay Roumans receives Dutch Diabetes Foundation grant

Kay Roumans recently received a grant from the Dutch Diabetes Foundation. This grant will enable him to set-up a new MRS measurement, that will be used to determine liver-specific gluconeogenesis. Next, Kay will investigate if gluconeogenesis is increased at night in people with prediabetes and whether lowering it helps to improve metabolic health. The study results can contribute to the development of new therapies in the future to prevent type 2 diabetes
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Publication by Froukje Vanweert on pharmacological activation of BCAA catabolism in patients with type 2 diabetes

The article from our colleague Froukje Vanweert is now online available and will be published in the Nature Communications with the following title: “A randomized placebo-controlled clinical trial for pharmacological activation of BCAA catabolism in patients with type 2 diabetes”. The full article can be found here: https://doi.org/10.1038/s41467-022-31249-9   Read the abstract below. Elevations in plasma branched-chain amino acid (BCAA) levels associate with insulin resistance ...
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New article: Healthy aging and muscle function are positively associated with NAD+ abundance in humans

In collaboration with Riekelt Houtkooper and Georges Janssens from Amsterdam UMC our colleagues Joris Hoeks and Lotte Grevendonk published their latest research on "healthy aging and muscle function are positively associated with NAD+ abundance in humans" in Nature Aging.  https://www.maastrichtuniversity.nl/news/energy-metabolism-muscles-active-seniors-almost-par-young-people The full article can be found here: https://rdcu.be/cHd4X   Read the abstract below. Skeletal muscle...
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New article on the influence of bright and dim light in insulin-resistant individuals

The article from our colleague Frieder Harmsen is now online available and will be published in the Diabetologia with the following title: “The influence of bright and dim light on substrate metabolism, energy expenditure and thermoregulation in insulin-resistant individuals depends on time of day”. The full article can be found here: https://link.springer.com/article/10.1007/s00125-021-05643-9 Read the abstract below. Aims/hypothesis In our modern society, artificial light is available ...
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