New article by Yvonne Bruls

Yvonne Bruls published her article titled "Carnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers with impaired glucose tolerance: A randomised controlled trial." in EBioMedicine. The full article can be found on https://doi.org/10.1016/j.ebiom.2019.10.017 Read the abstract below. BACKGROUND: Type 2 diabetes patients and individuals at risk of developing diabetes are characterized by metabolic inflexibility and disturbed glucose...
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New article by Lotte Grevendonk

Recently, Lotte Grevendonk was a co-author in the article titled "Older adults demonstrate interlimb transfer of reactive gait adaptations to repeated unpredictable gait perturbations.", published in Geroscience. The full article can be found on https://doi.org/10.1101/673574  Read the abstract below. The ability to rapidly adjust gait to cope with unexpected mechanical perturbations declines with ageing. Previous studies however, have not ensured that pre-perturbation gait stability was e...
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New article by Esther Phielix

Esther Phielix has published a new article titled "Athletes feature greater rates of muscle glucose transport and glycogen synthesis during lipid infusion" in the Journal of Clinical Investigation Insight. The full article can be found on https://doi.org/10.1172/jci.insight.127928  Read the abstract below. BACKGROUND: Insulin resistance results from impaired skeletal muscle glucose transport/phosphorylation, linked to augmented lipid availability. Despite greater intramuscular lipids, athlet...
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EFSD grant for Jan-Frieder Harmsen

Congratulations to our colleague Jan-Frieder Harmsen who secured a grant of the European Foundation for the Study of Diabetes (E FSD)! The project will focus on circadian rhythm and will build further on the previous day-night rhythm studies performed by our group. These studies revealed that pre-diabetes volunteers lack day-night rhythmicity in mitochondrial function and in 24h substrate metabolism in contrast to young healthy individuals. Moreover, the endogenous molecular clock in skel...
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New start in 2020

Today, most of our colleagues started to work again after well deserved holidays. Unfortunately, Maastricht University (UM) was hit by a serious cyberattack before Christmas. Despite a number of limitations, many activities could continue after the Christmas break without major problems. Some of our colleagues had to forego their Christmas break and (literally) work day and night. Others have sacrificed part of their vacation voluntarily to help. A big word of thanks to everyone for all their su...
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NVDO – Assessment of metabolic flexibility upon insulin stimulation and incremental submaximal exercise

During the NVDO meeting, Maaike Bergman presented her work on the assessment of metabolic flexibility upon insulin stimulation and incremental submaximal exercise. Metabolic flexibility is defined as the adaptability of substrate oxidation to substrate availability, which is commonly measured as the change in respiratory exchange ratio. In obese, metabolically compromised subjects, metabolic flexibility is disrupted, expressed by a blunted change from fat to glucose oxidation upon insulin sti...
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