New article by Pandi Veeraiah

Pandi, together with Kim Brouwers, Joachim Wildberger, Vera Schrauwen-Hinderling, and Lucas Lindeboom, published a new article on the 3rd of July on a new MR sequence for 13C-tracking experiments in human liver in Vivo titled: " ". This article is published in Magnetic Resonance in Medicine and the full article can be found here: https://doi.org/10.1002/mrm.28394 Read the abstract below: PURPOSE: Recently, we introduced a quantum coherence based method (ge‐HSQC) for indirect 13C‐MRS in the...
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Starting up clinical studies

Yes! We are starting up again with our clinical studies. Many projects came to a sudden halt because of all precaution measures regarding COVID-19. Although the start-up is slow, we are happy to be able to get back to our research unit and welcome participants again. Good luck to all our colleagues with getting back into the rhythm of screenings and test days!
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New article by Alex Houzelle

A manuscript of Alex Houzelle, former DMRG member and written together with some of the DMRG colleagues, is now online: "MicroRNA‐204‐5p modulates mitochondrial biogenesis in C2C12 myotubes and associates with oxidative capacity in humans". Published in Journal of Cellular Biology, the full article can be accessed with the following link: https://doi.org/10.1002/jcp.29797 Read the abstract below: Using an unbiased high‐throughput microRNA (miRNA)‐silencing screen combined with function...
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New article by Marlies de Ligt

A new article of our department with first author Marlies de Ligt is online now: "No effect of resveratrol supplementation after 6 months on insulin sensitivity in overweight adults: a randomized trial". This article is published in The American Journal of Clinical Nutrition and can be found on https://doi.org/10.1093/ajcn/nqaa125. Read the abstract below: BACKGROUND: Effects of resveratrol on metabolic health have been studied in several short-term human clinical trials, with conflicting ...
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Lab work starting up again!

Good news! We finally are able to start up the lab work again at our department! A bit lonely still with most of our colleagues still working from home, but happy to be able to start analyzing. Hopefully, we will soon be able to join our colleagues at Maastricht University. 
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New article with Matthijs Hesselink

Our colleague Matthijs Hesselink collaborated on a paper titled: "Lipid droplets accumulate in the hypothalamus of mice and humans with and without metabolic disease", published in Neuroendocrinology. The full article can be found on https://doi.org/10.1159/000508735 Read the abstract below: BACKGROUND: In peripheral tissues, the lipid droplet (LD) organelle links lipid metabolism, inflammation and insulin resistance. Little is known about the brain LDs. OBJECTIVES: We hypothesised that h...
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Digital get together

Although we are getting used to working from home, we still miss our colleagues: celebrating birthdays, having a chat at the coffee machine, or walking by somebody's office for a quick question. To keep each other updated and have an informal moment for interaction, we have biweekly meetings during which 2 colleagues talk about what they have been up to the last couple of weeks, work-related or personal. And of course, a quiz! Do we recognize each other's couches, backyard, and who would rather ...
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New article by Kay Roumans

Kay published a new article titled "Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance" in Nature Communications. The full article can be found on https://doi.org/10.1038/s41467-020-15684-0  Read the abstract below: Hepatic steatosis is associated with poor cardiometabolic health, with de novo lipogenesis (DNL) contributing to hepatic steatosis and subsequent insulin resistance. Hepatic saturated fatty acids (SFA) may be a marker...
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New article by DMRG members

Several of our DMRG members collaborated with the first author Hannah Pallubinsky for the article titled: "Passive exposure to heat improve glucose metabolism in overweight humans" in Acta Physiologica. The full article can be found on: https://doi.org/10.1111/apha.13488 Read the abstract below: AIM: Heat exposure has been indicated to positively affect glucose metabolism. An involvement of heat shock protein 72 (HSP72) in the enhancement of insulin sensitivity upon heat exposure has been ...
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New article by Carlijn Remie

Carlijn published a new article titled "Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans" in The American Journal of Clinical Nutrition. The full article can be found on: https://doi.org/10.1093/ajcn/nqaa072  Read the abstract below: BACKGROUND: Nicotinamide riboside (NR) is an NAD+ precursor that boosts cellular NAD+ concentrations. Preclinical studies have shown profound metabolic health effects after...
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