Publications

2023

Buitinga M, Veeraiah P, Haans F, Schrauwen-Hinderling VB. Ectopic lipid deposition in muscle and liver, quantified by proton magnetic resonance spectroscopy. Obesity. 2023 Oct. DOI: 10.1002/oby.23865.

de Wit-Verheggen VHW, Vanweert F, Raiko J, Liénard V, Schaart G, Gemmink A, Nascimento EBM, Hesselink MKC, Wildberger JE, Wierts R, Joris PJ, Haas J, Montaigne D, Staels B, Phielix E, Schrauwen P, Schrauwen-Hinderling VB, van de Weijer T. The tissue-specific metabolic effects of the PPARα agonist ciprofibrate in insulin-resistant male individuals: a double-blind, randomized, placebo-controlled crossover study. Obesity. 2023 Oct. DOI: 10.1002/oby.23874.

van Beek S, Hashim D, Bengtsson T, Hoeks J. Physiological and molecular mechanisms of cold-induced improvements in glucose homeostasis in humans beyond brown adipose tissue. Intnational Journal of Obersity. 2023 Feb 11. DOI: 10.1038/s41366-023-01270-z.

Roumans KHM, Veelen A, Andriessen C, Mevenkamp J, Kronips E, Veeraiah P, Havekes B, Peters HPF, Lindeboom L, Schrauwen P, Schrauwen-Hinderling VB. A prolonged fast improves overnight substrate oxidation without modulating hepatic glycogen in adults with and without nonalcoholic fatty liver: A randomized crossover trial. Obesity. 2023 Feb 9. DOI: 10.1002/oby.23676.

Basset-Sagarminaga J, Roumans KHM, Havekes B, Mensink RP, Peters HPF, de Mutsert R, Borén J, Lindeboom L, Schrauwen P, Schrauwen-Hinderling VB. Replacing Foods with a High-Glycemic Index and High in Saturated Fat by Alternatives with a Low Glycemic Index and Low Saturated Fat Reduces Hepatic Fat, Even in Isocaloric and Macronutrient Matched Conditions. Nutrients. 2023 Feb 1;15(3):735. DOI: 10.3390/nu15030735

van Beek SMM, Bruls YMH, Vanweert F, Fealy CE, Connell NJ, Schaart G, Moonen-Kornips E, Jörgensen JA, Vaz FM, Smeets ETHC, Joris PJ, Gemmink A, Houtkooper RH, Hesselink MKC, Bengtsson T, Havekes B, Schrauwen P, Hoeks J. Effect of β2-agonist treatment on insulin-stimulated peripheral glucose disposal in healthy men in a randomised placebo-controlled trial. Nature Communications. 2023 Jan 12;14(1):173. DOI: 10.1038/s41467-023-35798-5.

2022

Veelen A, Andriessen C, Op den Kamp Y, Erazo-Tapia E, de Ligt M, Mevenkamp J, Jörgensen JA, Moonen-Kornips E, Schaart G, Esterline R, Havekes B, Oscarsson J, Schrauwen-Hinderling VB, Phielix E, Schrauwen P. Effects of the sodium-glucose cotransporter 2 inhibitor dapagliflozin on substrate metabolism in prediabetic insulin resistant individuals: A randomized, double-blind crossover trial. Metabolism. 2022 Dec 30;155396. Doi: 10.1016/j.metabol.2022.155396. 

Harmsen JF, van Weeghel M, Parsons R, Janssens GE, Wefers J, van Moorsel D, Hansen J, Hoeks J, Hesselink MKC, Houtkooper HK, Schrauwen P. Divergent remodeling of the skeletal muscle metabolome over 24 h between young, healthy men and older, metabolically compromised men. Cell Rep. 2022 Dec 13;41(11):111786. DOI: 10.1016/j.celrep.2022.111786

Mancilla R, Lindeboom L, Grevendonk L, Hoek J, Koves TR, Muoio DM, Schrauwen P, Schrauwen-Hinderling VB, Hesselink MKC.  Skeletal muscle mitochondrial inertia associates with carnitine acetyltransferase activity and physical function in humans. JCI Insight. 2022 Nov 22;e163855. doi: 10.1172/jci.insight.163855.

Op den Kamp YJM, Gemmink A, de Ligt M, Dautzenberg B, Kornips E, Jorgensen JA, Schaart G, Esterline R, Pava DA, Hoeks, J, Schrauwen-Hinderling VB, Kersten S, Havekes B, Koves TR, Muoio DM, Hesselink MKC, Oscarsson J, Phielix E, Schrauwen P. Effects of SGLT2 inhibitor dapagliflozin in patients with type 2 diabetes on skeletal muscle cellular metabolism. Molecular metabolism. 22 Oct 21;101620. doi: 10.1016/j.molmet.2022.101620. 

Vanweert F, Schrauwen P, Phielix E. Role of branched-chain amino acid metabolism in the pathogenesis of obesity and type 2 diabetes-related metabolic disturbances BCAA metabolism in type 2 diabetes. Nutrition & Diabetes. 2022 Aug 5 ;12(1):35. doi: 10.1038/s41387-022-00213-3. PMCID: PMC9356071.

Andriesen C, Fealy CE, Veelen A, van Beek SMM, Roumans KHM, Connell NJ, Mevenkamp J, Moonen-Kornips E, Haveks B, Schrauwen-Hinderling VB, Hoeks J, Schrauwen P. Three weeks of time-restricted eating improves glucose homeostasis in adults with type 2 diabetes but does not improve insulin sensitivity: a randomised crossover trial. Diabetologia. 2022 Jul 25. doi: 10.1007/s00125-022-05752-z. PMID: 35871650.

Koene E, Schrauwen-Hinderling VB, Schrauwen P, Brouwers MCGJ. Novel insights in intestinal and hepatic fructose metabolism: from mice to men. Current opinion in clinical nutrition and metabolic care. 2022 Sep 1;25(5):354-359. doi: 10.1097/MCO.0000000000000853. PMID: 35838297.

Vanweert F, Neinast M, Erazo Tapia E, van de Weijer T, Hoeks J, Schrauwen-Hinderling VB, Blair MG, Bornstein MR, Hesselink MKC, Schrauwen P, Arany Z, Phielix E. A randomized placebo-controlled clinical trial for pharmacological activation of BCAA catabolism in patients with type 2 diabetes. Nature Communications. 2022 Jun 18;13(1):3508. doi: 10.1038/s41467-022-31249-9. PMCID: PMC9206682.

Harmsen JF, Wefers J, Doligkeit D, Schlangen L, Dautzenberg B, Rense P, van Moorsel D, Hoeks J, Moonen-Kornips E, Gordijn MCM, van Marken Lichtenbelt WP, Schrauwen P. The influence of bright and dim light on substrate metabolism, energy expenditure and thermoregulation in insulin-resistant individuals depends on time of day. Diabetologia. 2022 Apr;65(4):721-732. doi: 10.1007/s00125-021-05643-9. PMCID: PMC8894310.

Janssens GE, Grevendonk L, Zapeta Perez R, Schomakers BV, de Vogel-van den Bosch J, Geurts JMW, van Weeghel M, Schrauwen P, Houtkooper RH, Hoeks J. Healthy aging and muscle function are positively associated with NAD+ abundance in humans. Nature Aging. 2022 March voulme 2: 254–263. doi.org/10.1038/s43587-022-00174-3. https://rdcu.be/cHd4X.

2021

Boswijk E, de Ligt M, Habets MJ, Mingels AMA, van Marken Lichtenbelt WD, Mottaghy FM, Schrauwen P, Wildberger JE, Bucerius J. Resveratrol treatment does not reduce arterial inflammation in males at risk of type 2 diabetes: a randomized crossover trial. Nuklearmedizin. 2021 Dec 16. English. doi: 10.1055/a-1585-7215. PMID: 34918332.

Takeshita LY, Davidsen PK, Herbert JM, Antczak P, Hesselink MKC, Schrauwen P, Weisnagel SJ, Robbins JM, Gerszten RE, Ghosh S, Sarzynski MA, Bouchard C, Falciani F. Genomics and transcriptomics landscapes associated to changes in insulin sensitivity in response to endurance exercise training. Sci Rep. 2021 Dec 2;11(1):23314. doi: 10.1038/s41598-021-98792-1. PMID: 34857871; PMCID: PMC8639975.

de Wit-Verheggen VHW, van de Weijer T. Changes in Cardiac Metabolism in Prediabetes. Biomolecules. 2021 Nov 12;11(11):1680. doi: 10.3390/biom11111680. PMID: 34827678; PMCID: PMC8615987.

Vanweert F, de Ligt M, Hoeks J, Hesselink MKC, Schrauwen P, Phielix E. Elevated Plasma Branched-Chain Amino Acid Levels Correlate With Type 2 Diabetes-Related Metabolic Disturbances. J Clin Endocrinol Metab. 2021 Mar 25;106(4):e1827-e1836. doi: 10.1210/clinem/dgaa751. PMID: 33079174.

Remie CME, Janssens GE, Bilet L, van Weeghel M, Duvivier BMFM, de Wit VHW, Connell NJ, Jörgensen JA, Schomakers BV, Schrauwen-Hinderling VB, Hoeks J, Hesselink MKC, Phielix E, Houtkooper RH, Schrauwen P. Sitting less elicits metabolic responses similar to exercise and enhances insulin sensitivity in postmenopausal women. Diabetologia. 2021 Dec;64(12):2817-2828. doi: 10.1007/s00125-021-05558-5. Epub 2021 Sep 12. PMID: 34510226; PMCID: PMC8435176.

Fealy CE, Grevendonk L, Hoeks J, Hesselink MKC. Skeletal muscle mitochondrial network dynamics in metabolic disorders and aging. Trends Mol Med. 2021 Nov;27(11):1033-1044. doi: 10.1016/j.molmed.2021.07.013. Epub 2021 Aug 17. PMID: 34417125.

de Ligt M, Hesselink MKC, Jorgensen J, Hoebers N, Blaak EE, Goossens GH. Resveratrol supplementation reduces ACE2 expression in human adipose tissue. Adipocyte. 2021 Dec;10(1):408-411. doi: 10.1080/21623945.2021.1965315. PMID: 34402717.

Daemen S, van Polanen N, Bilet L, Phielix E, Moonen-Kornips E, Schrauwen-Hinderling VB, Schrauwen P, Hesselink MKC. Post-exercise changes in myocellular lipid droplet characteristics of young lean individuals are affected by circulatory non-esterified fatty acids. Am J Physiol Endocrinol Metab. 2021 Aug 16. doi: 10.1152/ajpendo.00654.2020. Epub ahead of print. PMID: 34396784.

Fealy CE, Grevendonk L, Hoeks J, Hesselink MKC. Skeletal muscle mitochondrial network dynamics in metabolic disorders and aging. Trends Mol Med. 2021 Aug 17:S1471-4914(21)00198-2. doi: 10.1016/j.molmed.2021.07.013. Epub ahead of print. PMID: 34417125.

Grevendonk L, Connell NJ, McCrum C, Fealy CE, Bilet L, Bruls YMH, Mevenkamp J, Schrauwen-Hinderling VB, Jörgensen JA, Moonen-Kornips E, Schaart G, Havekes B, de Vogel-van den Bosch J, Bragt MCE, Meijer K, Schrauwen P, Hoeks J. Impact of aging and exercise on skeletal muscle mitochondrial capacity, energy metabolism, and physical function. Nat Commun. 2021 Aug 6;12(1):4773. doi: 10.1038/s41467-021-24956-2. PMID: 34362885; PMCID: PMC8346468.

Simons PIHG, Valkenburg O, Telgenkamp I, van der Waaij KM, de Groot DM, Veeraiah P, Bons JAP, Taskinen MR, Borén J, Schrauwen P, Rutten JHW, Cassiman D, Schalkwijk CG, Stehouwer CDA, Schrauwen-Hinderling VB, Hodson L, Brouwers MCGJ. Relationship between de novo lipogenesis and serum sex hormone binding globulin in humans. Clin Endocrinol (Oxf). 2021 Jul;95(1):101-106. doi: 10.1111/cen.14459. Epub 2021 Mar 28. PMID: 33715205; PMCID: PMC8287427.

Vanweert F, Boone SC, Brouwers B, Mook-Kanamori DO, de Mutsert R, Rosendaal FR, Lamb HJ, Schrauwen-Hinderling VB, Schrauwen P, Hesselink MKC, Phielix E. The effect of physical activity level and exercise training on the association between plasma branched-chain amino acids and intrahepatic lipid content in participants with obesity. Int J Obes (Lond). 2021 Jul;45(7):1510-1520. doi: 10.1038/s41366-021-00815-4. Epub 2021 May 2. PMID: 33935282; PMCID: PMC8236400.

van Meijel RLJ, Vogel MAA, Jocken JWE, Vliex LMM, Smeets JSJ, Hoebers N, Hoeks J, Essers Y, Schoffelen PFM, Sell H, Kersten S, M A Rouschop K, Blaak EE, Goossens GH. Mild intermittent hypoxia exposure induces metabolic and molecular adaptations in men with obesity. Mol Metab. 2021 Jul 3;53:101287. doi: 10.1016/j.molmet.2021.101287. Epub ahead of print. PMID: 34224918; PMCID: PMC8355948.

Connell NJ, Grevendonk L, Fealy CE, Moonen-Kornips E, Bruls YMH, Schrauwen-Hinderling VB, de Vogel J, Hageman R, Geurts J, Zapata-Perez R, Houtkooper RH, Havekes B, Hoeks J, Schrauwen P. NAD+-Precursor Supplementation With L-Tryptophan, Nicotinic Acid, and Nicotinamide Does Not Affect Mitochondrial Function or Skeletal Muscle Function in Physically Compromised Older Adults. J Nutr. 2021 Jun 30:nxab193. doi: 10.1093/jn/nxab193. Epub ahead of print. PMID: 34191033.

Lagerwaard B, van der Hoek MD, Hoeks J, Grevendonk L, Nieuwenhuizen AG, Keijer J, de Boer VCJ. Propionate hampers differentiation and modifies histone propionylation and acetylation in skeletal muscle cells. Mech Ageing Dev. 2021 Jun;196:111495. doi: 10.1016/j.mad.2021.111495. Epub 2021 Apr 28. PMID: 33932454.

Jansen CJM, Koops van ‘t Jagt R, Reijneveld SA, van Leeuwen E, de Winter AF, Hoeks JCJ. Improving Health Literacy Responsiveness: A Randomized Study on the Uptake of Brochures on Doctor-Patient Communication in Primary Health Care Waiting Rooms. Int J Environ Res Public Health. 2021 May 10;18(9):5025. doi: 10.3390/ijerph18095025. PMID: 34068577; PMCID: PMC8126085.

de Ligt M, Hesselink MKC, Jorgensen J, Jocken JWE, Blaak EE, Goossens GH. The angiotensin II type 1 receptor blocker valsartan in the battle against COVID-19. Obesity (Silver Spring). 2021 May 5:10.1002/oby.23221. doi: 10.1002/oby.23221. Epub ahead of print. PMID: 33955183; PMCID: PMC8242711.

Nascimento EBM, Moonen MPB, Remie CME, Gariani K, Jörgensen JA, Schaart G, Hoeks J, Auwerx J, van Marken Lichtenbelt WD, Schrauwen P. Nicotinamide Riboside Enhances In Vitro Beta-adrenergic Brown Adipose Tissue Activity in Humans. J Clin Endocrinol Metab. 2021 Apr 23;106(5):1437-1447. doi: 10.1210/clinem/dgaa960. PMID: 33524145.

Veelen A, Erazo-Tapia E, Oscarsson J, Schrauwen P. Type 2 diabetes subgroups and potential medication strategies in relation to effects on insulin resistance and beta-cell function: A step toward personalised diabetes treatment? Mol Metab. 2021 Apr;46:101158. doi: 10.1016/j.molmet.2020.101158. Epub 2020 Dec 30. PMID: 33387681; PMCID: PMC8085543.

Winters-van Eekelen E, Verkouter I, Peters HPF, Alssema M, de Roos BG, Schrauwen-Hinderling VB, Roumans KHM, Schoones JW, Zock PL, Schrauwen P, Rosendaal FR, Dekkers OM, de Mutsert R. Effects of dietary macronutrients on liver fat content in adults: a systematic review and meta-analysis of randomized controlled trials. Eur J Clin Nutr. 2021 Apr;75(4):588-601. doi: 10.1038/s41430-020-00778-1. Epub 2020 Oct 22. PMID: 33087892.

Remie CME, Moonen MPB, Roumans KHM, Nascimento EBM, Gemmink A, Havekes B, Schaart G, Kornips E, Joris PJ, Schrauwen-Hinderling VB, Hoeks J, Kersten S, Hesselink MKC, Phielix E, Lichtenbelt WDVM, Schrauwen P. Metabolic responses to mild cold acclimation in type 2 diabetes patients. Nat Commun. 2021 Mar 9;12(1):1516. doi: 10.1038/s41467-021-21813-0. PMID: 33750795; PMCID: PMC7943816.

van Beek SMM, Kalinovich A, Schaart G, Bengtsson T, Hoeks J. Prolonged β2-adrenergic agonist treatment improves glucose homeostasis in diet-induced obese UCP1-/- mice. Am J Physiol Endocrinol Metab. 2021 Mar 1;320(3):E619-E628. doi: 10.1152/ajpendo.00324.2020. Epub 2021 Feb 1. PMID: 33522400.

Simons N, Veeraiah P, Simons PIHG, Schaper NC, Kooi ME, Schrauwen-Hinderling VB, Feskens EJM, van der Ploeg EMCL, Van den Eynde MDG, Schalkwijk CG, Stehouwer CDA, Brouwers MCGJ. Effects of fructose restriction on liver steatosis (FRUITLESS); a double-blind randomized controlled trial. Am J Clin Nutr. 2021 Feb 2;113(2):391-400. doi: 10.1093/ajcn/nqaa332. PMID: 33381794; PMCID: PMC7851818.

Connell NJ, Doligkeit D, Andriessen C, Kornips-Moonen E, Bruls YMH, Schrauwen-Hinderling VB, van de Weijer T, van Marken-Lichtenbelt WD, Havekes B, Kazak L, Spiegelman BM, Hoeks J, Schrauwen P. No evidence for brown adipose tissue activation after creatine supplementation in adult vegetarians. Nat Metab. 2021 Jan;3(1):107-117. doi: 10.1038/s42255-020-00332-0. Epub 2021 Jan 18. PMID: 33462512.

Schött HF, Konings MCJM, Schrauwen-Hinderling VB, Mensink RP, Plat J. A Validated Method for Quantification of Fatty Acids Incorporated in Human Plasma Phospholipids by Gas Chromatography-Triple Quadrupole Mass Spectrometry. ACS Omega. 2021 Jan 4;6(2):1129-1137. doi: 10.1021/acsomega.0c03874. PMID: 33490772; PMCID: PMC7818123.

Mancilla R, Brouwers B, Schrauwen-Hinderling VB, Hesselink MKC, Hoeks J, Schrauwen P. Exercise training elicits superior metabolic effects when performed in the afternoon compared to morning in metabolically compromised humans. Physiol Rep. 2021 Jan;8(24):e14669. doi: 10.14814/phy2.14669. PMID: 33356015; PMCID: PMC7757369.

2020

Houzelle A, Jörgensen JA, Schaart G, Daemen S, van Polanen N, Fealy CE, Hesselink MKC, Schrauwen P, Hoeks J. Human skeletal muscle mitochondrial dynamics in relation to oxidative capacity and insulin sensitivity. Diabetologia. 2020 Nov 30. doi: 10.1007/s00125-020-05335-w. Epub ahead of print. PMID: 33258025.

Andriessen C, Schrauwen P, Hoeks J. The importance of 24-h metabolism in obesity-related metabolic disorders: opportunities for timed interventions. Int J Obes (Lond). 2020 Nov 24. doi: 10.1038/s41366-020-00719-9. Epub ahead of print. PMID: 33235354.

Roumans KHM, Basset Sagarminaga J, Peters HPF, Schrauwen P, Schrauwen-Hinderling VB. Liver fat storage pathways: methodologies and dietary effects. Curr Opin Lipidol. 2020 Nov 23. doi: 10.1097/MOL.0000000000000720. Epub ahead of print. PMID: 33234776.

Smeets ETHC, Mensink RP, Hoeks J, de Vogel-Van den Bosch J, Hageman RJJ, Joris PJ. Effects of Beetroot Powder with or without L-Arginine on Postprandial Vascular Endothelial Function: Results of a Randomized Controlled Trial with Abdominally Obese Men. Nutrients. 2020 Nov 16;12(11):3520. doi: 10.3390/nu12113520. PMID: 33207606; PMCID: PMC7697292.

Gemmink A, Daemen S, Brouwers B, Hoeks J, Schaart G, Knoops K, Schrauwen P, Hesselink MKC. Decoration of myocellular lipid droplets with perilipins as a marker for in vivo lipid droplet dynamics: A super-resolution microscopy study in trained athletes and insulin resistant individuals. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Nov 4:158852. doi: 10.1016/j.bbalip.2020.158852. Epub ahead of print. PMID: 33160079.

Wefers J, Connell NJ, Fealy CE, Andriessen C, de Wit V, van Moorsel D, Moonen-Kornips E, Jörgensen JA, Hesselink MKC, Havekes B, Hoeks J, Schrauwen P. Day-night rhythm of skeletal muscle metabolism is disturbed in older, metabolically compromised individuals. Mol Metab. 2020 Nov;41:101050. doi: 10.1016/j.molmet.2020.101050. Epub 2020 Jul 11. PMID: 32659272; PMCID: PMC7415921.

Vanweert F, de Ligt M, Hoeks J, Hesselink MKC, Schrauwen P, Phielix E. Elevated plasma branched-chain amino acid levels correlate with type 2 diabetes-related metabolic disturbances. J Clin Endocrinol Metab. 2020 Oct 20:dgaa751. doi: 10.1210/clinem/dgaa751. Epub ahead of print. PMID: 33079174.

de Ligt M, Bergman M, Fuentes RM, Essers H, Moonen-Kornips E, Havekes B, Schrauwen-Hinderling VB, Schrauwen P. No effect of resveratrol supplementation after 6 months on insulin sensitivity in overweight adults: a randomized trial. Am J Clin Nutr. 2020 Oct 1;112(4):1029-1038. doi: 10.1093/ajcn/nqaa125. PMID: 32492138; PMCID: PMC7528554.

Nascimento EBM, Hangelbroek RWJ, Hooiveld GJEJ, Hoeks J, Van Marken Lichtenbelt WD, Hesselink MHC, Schrauwen P, Kersten S. Comparative transcriptome analysis of human skeletal muscle in response to cold acclimation and exercise training in human volunteers. BMC Med Genomics. 2020 Sep 4;13(1):124. doi: 10.1186/s12920-020-00784-z. PMID: 32887608; PMCID: PMC7487556.

Daemen S, Gemmink A, Paul A, Billecke N, Rieger K, Parekh SH, Hesselink MKC. Label-free CARS microscopy reveals similar triacylglycerol acyl chain length and saturation in myocellular lipid droplets of athletes and individuals with type 2 diabetes. Diabetologia. 2020 Sep 3. doi: 10.1007/s00125-020-05266-6. Epub ahead of print. PMID: 32880685.

Fechner E, Bilet L, Peters HPF, Hiemstra H, Jacobs DM, Op ‘t Eyndt C, Kornips E, Mensink RP, Schrauwen P. Effects of a whole diet approach on metabolic flexibility, insulin sensitivity and postprandial glucose responses in overweight and obese adults – A randomized controlled trial. Clin Nutr. 2020 Sep;39(9):2734-2742. doi: 10.1016/j.clnu.2019.12.010. Epub 2019 Dec 17. PMID: 31899037.

Bruls YMH, Op den Kamp YJM, Phielix E, Lindeboom L, Havekes B, Schaart G, Moonen-Kornips E, Wildberger JE, Hesselink MKC, Schrauwen P and Schrauwen-Hinderling VB (2020). L-carnitine infusion does not alleviate lipid-induced insulin resistance and metabolic inflexibility. PLoS One, 15(9), e0239506. doi:10.1371/journal.pone.0239506

Daemen S, Gemmink A, Paul A, Billecke N, Rieger K, Parekh SH, et al. Label-free CARS microscopy reveals similar triacylglycerol acyl chain length and saturation in myocellular lipid droplets of athletes and individuals with type 2 diabetes. Diabetologia. 2020.

Nascimento EBM, Hangelbroek RWJ, Hooiveld GJEJ, Hoeks J, Van Marken Lichtenbelt WD, Hesselink MHC, et al. Comparative transcriptome analysis of human skeletal muscle in response to cold acclimation and exercise training in human volunteers. BMC Medical Genomics. 2020;13(1):124.

Houzelle A, Dahlmans D, Nascimento EBM, et al. MicroRNA-204-5p modulates mitochondrial biogenesis in C2C12 myotubes and associates with oxidative capacity in humans [published online ahead of print, 2020 May 26]. J Cell Physiol. 2020;10.1002/jcp.29797. doi:10.1002/jcp.29797

Roumans KHM, Lindeboom L, Veeraiah P, Remie CME, Phielix E, Havekes B, et al. Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance. Nature communications. 2020;11(1):1891.

Remie CME, Roumans KHM, Moonen MPB, Connell NJ, Havekes B, Mevenkamp J, et al. Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. The American journal of clinical nutrition. 2020.

Carper D, Coué M, Nascimento EBM, Barquissau V, Lagarde D, Pestourie C, Laurens C, Petit JV, Soty M, Monbrun L, Marques MA, Jeanson Y, Sainte-Marie Y, Mairal A, Déjean S, Tavernier G, Viguerie N, Bourlier V, Lezoualc’h F, Carrière A, Saris WHM, Astrup A, Casteilla L, Mithieux G, van Marken Lichtenbelt W, Langin D, Schrauwen P, Moro C. Atrial Natriuretic Peptide Orchestrates a Coordinated Physiological Response to Fuel Non-shivering Thermogenesis. Cell Rep. 2020 Aug 25;32(8):108075. doi: 10.1016/j.celrep.2020.108075. PMID: 32846132.

Held NM, Wefers J, van Weeghel M, Daemen S, Hansen J, Vaz FM, van Moorsel D, Hesselink MKC, Houtkooper RH, Schrauwen P. Skeletal muscle in healthy humans exhibits a day-night rhythm in lipid metabolism. Mol Metab. 2020 Jul;37:100989. doi: 10.1016/j.molmet.2020.100989. Epub 2020 Apr 6. PMID: 32272236; PMCID: PMC7217992.

Veeraiah P, Brouwers K, Wildberger JE, Schrauwen-Hinderling VB, Lindeboom L. Application of a BIlinear Rotation Decoupling (BIRD) filter in combination with J-difference editing for indirect 13 C measurements in the human liver. Magn Reson Med. 2020 Jul 3;84(6):2911–7. doi: 10.1002/mrm.28394. Epub ahead of print. PMID: 32618391; PMCID: PMC7540382.

Kalsbeek A, Schrauwen P. Muscle Clocks and Diabetes. Obesity (Silver Spring). 2020 Jul;28 Suppl 1:S5. doi: 10.1002/oby.22906. PMID: 32700825.

Gemmink A, Schrauwen P, Hesselink MKC. Exercising your fat (metabolism) into shape: a muscle-centred view. Diabetologia. 2020 Aug;63(8):1453-1463. doi: 10.1007/s00125-020-05170-z. Epub 2020 Jun 12. PMID: 32529413; PMCID: PMC7351830.

Pallubinsky H, Phielix E, Dautzenberg B, Schaart G, Connell NJ, de Wit-Verheggen V, et al. Passive exposure to heat improves glucose metabolism in overweight humans. Acta Physiol (Oxf). 2020;n/a(n/a):e13488.

2019

Wulan SN, Schrauwen-Hinderling VB, Westerterp KR, Plasqui G. Substrate utilization and metabolic profile in response to overfeeding with a high-fat diet in South Asian and white men: a sedentary lifestyle study. International journal of obesity (2005). 2019;44(1):136-46.

van Eekelen E, Beulens JWJ, Geelen A, Schrauwen-Hinderling VB, Lamb H, de Roos A, et al. Consumption of Alcoholic and Sugar-Sweetened Beverages is Associated with Increased Liver Fat Content in Middle-Aged Men and Women. J Nutr. 2019;149(4):649-58.

van de Weijer T, Schrauwen-Hinderling VB. Application of Magnetic Resonance Spectroscopy in metabolic research. Biochimica et biophysica acta Molecular basis of disease. 2019;1865(4):741-8.

Telgenkamp I, Kusters Y, Schalkwijk CG, Houben A, Kooi ME, Lindeboom L, et al. Contribution of Liver Fat to Weight Loss-Induced Changes in Serum Hepatokines: A Randomized Controlled Trial. The Journal of clinical endocrinology and metabolism. 2019;104(7):2719-27.

Stenvers DJ, Scheer F, Schrauwen P, la Fleur SE, Kalsbeek A. Circadian clocks and insulin resistance. Nature reviews Endocrinology. 2019;15(2):75-89.

Simons N, Debray FG, Schaper NC, Kooi ME, Feskens EJM, Hollak CEM, et al. Patients with aldolase B deficiency are characterized by an increased intrahepatic triglyceride content. The Journal of clinical endocrinology and metabolism. 2019;104(11):5056-64.

Rouschop SH, Karl T, Risch A, van Ewijk PA, Schrauwen-Hinderling VB, Opperhuizen A, et al. Gene expression and DNA methylation as mechanisms of disturbed metabolism in offspring after exposure to a prenatal HF diet. Journal of lipid research. 2019;60(7):1250-9.

Paulus A, van Ewijk PA, Nascimento EBM, De Saint-Hubert M, Hendrikx G, Vogg A, et al. Characterization of BAT activity in rats using invasive and non-invasive techniques. PloS one. 2019;14(5):e0215852.

Paulus A, Drude N, Nascimento EBM, Buhl EM, Berbee JFP, Rensen PCN, et al. [(18)F]BODIPY-triglyceride-containing chylomicron-like particles as an imaging agent for brown adipose tissue in vivo. Scientific reports. 2019;9(1):2706.

Nascimento EBM, Konings M, Schaart G, Groen AK, Lutjohann D, van Marken Lichtenbelt WD, et al. In vitro effects of sitosterol and sitostanol on mitochondrial respiration in human brown adipocytes, myotubes and hepatocytes. Eur J Nutr. 2019.

De Mutsert R. Visceral fat and liver fat in relation to type 2 diabetes in 10 years of follow-up. In: Group EDE, editor. Oral presentation ed. Mondorf Domaine, Luxembourg2019.

Dahlmans D, Houzelle A, Andreux P, Wang X, Jorgensen JA, Moullan N, et al. MicroRNA-382 silencing induces a mitonuclear protein imbalance and activates the mitochondrial unfolded protein response in muscle cells. Journal of cellular physiology. 2019;234(5):6601-10.

Connell NJ, Houtkooper RH, Schrauwen P. NAD(+) metabolism as a target for metabolic health: have we found the silver bullet? Diabetologia. 2019;62(6):888-99.

Connell NJ, Houtkooper RH, Schrauwen P. Underpowered or negative? A crucial distinction. Reply to Dollerup OL, Treebak JT, Jessen N [letter]. Diabetologia. 2019;62(6):1096.

Boswijk E, Sanders KJC, Broeders EPM, de Ligt M, Vijgen G, Havekes B, et al. TSH suppression aggravates arterial inflammation – an (18)F-FDG PET study in thyroid carcinoma patients. European journal of nuclear medicine and molecular imaging. 2019;46(7):1428-38.

Boon MR, Hanssen MJW, Brans B, Hulsman CJM, Hoeks J, Nahon KJ, et al. Effect of L-arginine on energy metabolism, skeletal muscle and brown adipose tissue in South Asian and Europid prediabetic men: a randomised double-blinded crossover study. Diabetologia. 2019;62(1):112-22.

2018

Zacharewicz E, Hesselink MKC, Schrauwen P. Exercise counteracts lipotoxicity by improving lipid turnover and lipid droplet quality. Journal of internal medicine. 2018;284(5):505-18.

Wefers J, van Moorsel D, Hansen J, Connell NJ, Havekes B, Hoeks J, et al. Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America. 2018;115(30):7789-94.

Veeraiah P, Roumans KHM, Wildberger JE, Schrauwen P, Schrauwen-Hinderling VB, Lindeboom L. Reproducibility of the measurement of hepatic lipid composition with 1H MRS at 3T. In: ISMRM-ESMRMB, editor. Poster presentation ed. Paris, FR2018.

van den Berg R, Kooijman S, Noordam R, Ramkisoensing A, Abreu-Vieira G, Tambyrajah LL, et al. A Diurnal Rhythm in Brown Adipose Tissue Causes Rapid Clearance and Combustion of Plasma Lipids at Wakening. Cell Rep. 2018;22(13):3521-33.

Stinkens R, Brouwers B, Jocken JW, Blaak EE, Teunissen-Beekman KF, Hesselink MK, et al. Exercise training-induced effects on the abdominal subcutaneous adipose tissue phenotype in humans with obesity. Journal of applied physiology (Bethesda, Md : 1985). 2018;125(5):1585-93.

Schrauwen-Hinderling VB, Schols A. Imaging in metabolic research: challenges and opportunities. Journal of applied physiology (Bethesda, Md : 1985). 2018;124(1):jap009062017.

Schrauwen-Hinderling VB, Carpentier AC. Molecular imaging of postprandial metabolism. Journal of applied physiology (Bethesda, Md : 1985). 2018;124(2):504-11.

Schrauwen P. Mitochondrial dysfunction in skeletal muscle and type 2 diabetes. In: 2018 Nw, editor. Invited Keynote speaker at the 2018 NUGO week – mitochondria, nutrition and health ed. New Castle, UK2018.

Sanders D, Heijboer M, Hesselink MKC, Myers T, Akubat I. Analysing a cycling grand tour: Can we monitor fatigue with intensity or load ratios? Journal of sports sciences. 2018;36(12):1385-91.

Roumans KHM, Veeraiah P, Lindeboom L, Phielix E, Havekes B, Schrauwen P, et al. De novo lipogenesis as a determinant of liver fat composition in overweight and obese people. In: conference Ec, editor. Poster presentation ed. Leiden, NL2018.

Nies M, Dekker BL, Sulkers E, Huizinga GA, Klein Hesselink MS, Maurice-Stam H, et al. Psychosocial development in survivors of childhood differentiated thyroid carcinoma: a cross-sectional study. European journal of endocrinology. 2018;178(3):215-23.

Nascimento EBM, Sparks LM, Divoux A, van Gisbergen MW, Broeders EPM, Jorgensen JA, et al. Genetic Markers of Brown Adipose Tissue Identity and In Vitro Brown Adipose Tissue Activity in Humans. Obesity (Silver Spring, Md). 2018;26(1):135-40.

Lindeboom L, de Graaf RA. Measurement of lipid composition in human skeletal muscle and adipose tissue with (1) H-MRS homonuclear spectral editing. Magn Reson Med. 2018;79(2):619-27.

Lancel S, Hesselink MK, Woldt E, Rouille Y, Dorchies E, Delhaye S, et al. Endospanin-2 enhances skeletal muscle energy metabolism and running endurance capacity. JCI Insight. 2018;3(9).

Huizinga P, Schrauwen E, Garcia-Cobos S, Willemsen I, Verhulst C, Friedrich AW, et al. Extended-spectrum beta-lactamase producing Enterobacteriaceae (ESBL-E) isolated from bean sprouts in the Netherlands. PloS one. 2018;13(8):e0203338.

Gemmink A, Daemen S, Kuijpers HJH, Schaart G, Duimel H, Lopez-Iglesias C, et al. Super-resolution microscopy localizes perilipin 5 at lipid droplet-mitochondria interaction sites and at lipid droplets juxtaposing to perilipin 2. Biochimica et biophysica acta Molecular and cell biology of lipids. 2018;1863(11):1423-32.

Gemmink A, Daemen S, Brouwers B, Huntjens PR, Schaart G, Moonen-Kornips E, et al. Dissociation of intramyocellular lipid storage and insulin resistance in trained athletes and type 2 diabetes patients; involvement of perilipin 5? The Journal of physiology. 2018;596(5):857-68.

Defour M, Dijk W, Ruppert P, Nascimento EBM, Schrauwen P, Kersten S. The Peroxisome Proliferator-Activated Receptor α is dispensable for cold-induced adipose tissue browning in mice. Molecular metabolism. 2018;10:39-54.

Defour M, Dijk W, Ruppert P, Nascimento EBM, Schrauwen P, Kersten S. The Peroxisome Proliferator-Activated Receptor alpha is dispensable for cold-induced adipose tissue browning in mice. Molecular metabolism. 2018;10:39-54.

de Ligt M, Bruls YMH, Hansen J, Habets MF, Havekes B, Nascimento EBM, et al. Resveratrol improves ex vivo mitochondrial function but does not affect insulin sensitivity or brown adipose tissue in first degree relatives of patients with type 2 diabetes. Molecular metabolism. 2018;12:39-47.

de Goede P, Wefers J, Brombacher EC, Schrauwen P, Kalsbeek A. Circadian rhythms in mitochondrial respiration. J Mol Endocrinol. 2018;60(3):R115-R30.

Daemen S, van Polanen N, Hesselink MKC. The effect of diet and exercise on lipid droplet dynamics in human muscle tissue. The Journal of experimental biology. 2018;221(Suppl 1):jeb167015.

Daemen S, Gemmink A, Brouwers B, Meex RCR, Huntjens PR, Schaart G, et al. Distinct lipid droplet characteristics and distribution unmask the apparent contradiction of the athlete’s paradox. Molecular metabolism. 2018;17:71-81.

Clemmensen, C., S. Jall, M. Kleinert, C. Quarta, T. Gruber, J. Reber, S. Sachs, K. Fischer, A. Feuchtinger, A. Karlas, S. E. Simonds, G. Grandl, D. Loher, E. Sanchez-Quant, S. Keipert, M. Jastroch, S. M. Hofmann, E. B. M. Nascimento, P. Schrauwen, V. Ntziachristos, M. A. Cowley, B. Finan, T. D. Muller and M. H. Tschop:.Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes. Nature communications. 2018;9(1):4304.

Brouwers, B., V. B. Schrauwen-Hinderling, T. Jelenik, A. Gemmink, L. M. Sparks, B. Havekes, Y. Bruls, D. Dahlmans, M. Roden, M. K. C. Hesselink and P. Schrauwen. Exercise training reduces intrahepatic lipid content in people with and people without nonalcoholic fatty liver. American journal of physiology Endocrinology and metabolism. 2018;314(2):E165-E73.

2017

Schreiber, R., C. Diwoky, G. Schoiswohl, U. Feiler, N. Wongsiriroj, M. Abdellatif, D. Kolb, J. Hoeks, E. E. Kershaw, S. Sedej, P. Schrauwen, G. Haemmerle and R. Zechner. Cold-Induced Thermogenesis Depends on ATGL-Mediated Lipolysis in Cardiac Muscle, but Not Brown Adipose Tissue. Cell Metab. 2017;26(5):753-63 e7.

Schrauwen P, van Marken Lichtenbelt W. Brown adipose tissue: The magic bullet? Obesity (Silver Spring, Md). 2017;25(3):499.

Peters HPF, Schrauwen P, Verhoef P, Byrne CD, Mela DJ, Pfeiffer AFH, et al. Liver fat: a relevant target for dietary intervention? Summary of a Unilever workshop. Journal of nutritional science. 2017;6:e15.

Nies M, Klein Hesselink MS, Huizinga GA, Sulkers E, Brouwers AH, Burgerhof JGM, et al. Long-Term Quality of Life in Adult Survivors of Pediatric Differentiated Thyroid Carcinoma. The Journal of clinical endocrinology and metabolism. 2017;102(4):1218-26.

Lindeboom L, Bruls YM, Ewijk PA, Hesselink MK, Wildberger JE, Schrauwen P, et al. Longitudinal relaxation time editing for acetylcarnitine detection with 1H‐MRS. Magnetic resonance in medicine. 2017;77(2):505-10.

Kusters YH, Schalkwijk CG, Houben AJ, Kooi ME, Lindeboom L, Op ‘t Roodt J, et al. Independent tissue contributors to obesity-associated insulin resistance. JCI Insight. 2017;2(13).

Kodde A, van der Beek EM, Phielix E, Engels E, Schipper L, Oosting A. Supramolecular structure of dietary fat in early life modulates expression of markers for mitochondrial content and capacity in adipose tissue of adult mice. Nutrition & metabolism. 2017;14:37.

Hesselink MKC, Daemen S, van Polanen N, Gemmink A. What are the benefits of being big? The Journal of physiology. 2017;595(16):5409-10.

Gosens W, Van’t Hul AJ, Oomen JM, Hesselink MK, Borghouts LB. Mechanical Efficiency in Chronic Obstructive Pulmonary Disease. Journal of cardiopulmonary rehabilitation and prevention. 2017;37(2):146-53.

Gemmink A, Goodpaster BH, Schrauwen P, Hesselink MKC. Intramyocellular lipid droplets and insulin sensitivity, the human perspective. Biochimica et Biophysica Acta (BBA) – Molecular and Cell Biology of Lipids. 2017;1862(10, Part B):1242-9.

Gemmink A, Bakker LEH, Guigas B, Kornips E, Schaart G, Meinders AE, et al. Lipid droplet dynamics and insulin sensitivity upon a 5-day high-fat diet in Caucasians and South Asians. Scientific reports. 2017;7:42393.

Gemmink A, Bakker LE, Guigas B, Kornips E, Schaart G, Meinders AE, et al. Lipid droplet dynamics and insulin sensitivity upon a 5-day high-fat diet in Caucasians and South Asians. Scientific reports. 2017;7:42393.

Duvivier BM, Schaper NC, Hesselink MK, van Kan L, Stienen N, Winkens B, et al. Breaking sitting with light activities vs structured exercise: a randomised crossover study demonstrating benefits for glycaemic control and insulin sensitivity in type 2 diabetes. Diabetologia. 2017;60(3):490-8.

de Ligt M, Timmers S, Schrauwen P. Response to Comment on Timmers et al. Resveratrol as Add-on Therapy in Subjects With Well-Controlled Type 2 Diabetes: A Randomized Controlled Trial. Diabetes Care 2016;39:2211-2217. Diabetes care. 2017;40(9):e134.

Dahlmans D, Houzelle A, Jorgensen JA, Phielix E, Lindeboom L, Hesselink MKC, et al. Evaluation of Muscle microRNA Expression in Relation to Human Peripheral Insulin Sensitivity: A Cross-Sectional Study in Metabolically Distinct Subject Groups. Front Physiol. 2017;8:711.

Dahlmans D, Houzelle A, Andreux P, Jorgensen JA, Wang X, de Windt LJ, et al. An unbiased silencing screen in muscle cells identifies miR-320a, miR-150, miR-196b, and miR-34c as regulators of skeletal muscle mitochondrial metabolism. Molecular metabolism. 2017;6(11):1429-42.

Coleman RA, Hesselink MK. Recent advances in lipid droplet biology. Biochimica et Biophysica Acta (BBA) – Molecular and Cell Biology of Lipids. 2017;1862(10, Part B):1129-30.

Brouwers B, Schrauwen-Hinderling VB, Jelenik T, Gemmink A, Havekes B, Bruls Y, et al. Metabolic disturbances of non-alcoholic fatty liver resemble the alterations typical for type 2 diabetes. Clinical science (London, England : 1979). 2017;131(15):1905-17.

2016

van Moorsel D, Hansen J, Havekes B, Scheer F, Jorgensen JA, Hoeks J, et al. Demonstration of a day-night rhythm in human skeletal muscle oxidative capacity. Molecular metabolism. 2016;5(8):635-45.

van Bree BW, Lenaers E, Nabben M, Briede JJ, Jorgensen JA, Schaart G, et al. A genistein-enriched diet neither improves skeletal muscle oxidative capacity nor prevents the transition towards advanced insulin resistance in ZDF rats. Scientific reports. 2016;6:22854.

Timmers S, de Ligt M, Phielix E, van de Weijer T, Hansen J, Moonen-Kornips E, et al. Resveratrol as Add-on Therapy in Subjects With Well-Controlled Type 2 Diabetes: A Randomized Controlled Trial. Diabetes care. 2016;39(12):2211-7.

Sparks LM, Gemmink A, Phielix E, Bosma M, Schaart G, Moonen-Kornips E, et al. ANT1-mediated fatty acid-induced uncoupling as a target for improving myocellular insulin sensitivity. Diabetologia. 2016;59(5):1030-9.

Schrauwen-Hinderling VB, Kooi ME, Schrauwen P. Mitochondrial Function and Diabetes: Consequences for Skeletal and Cardiac Muscle Metabolism. Antioxidants & redox signaling. 2016;24(1):39-51.

Most J, Timmers S, Warnke I, Jocken JW, van Boekschoten M, de Groot P, Bendik I, Schrauwen P, Goossens GH, Blaak EE. Combined epigallocatechin-3-gallate and resveratrol supplementation for 12 wk increases mitochondrial capacity and fat oxidation, but not insulin sensitivity, in obese humans: a randomized controlled trial. The American journal of clinical nutrition. 2016;104(1):215-27.

Lindeboom L, de Graaf RA, Nabuurs CI, van Ewijk PA, Hesselink MK, Wildberger JE, et al. Quantum coherence spectroscopy to measure dietary fat retention in the liver. JCI Insight. 2016;1(13):e84671.

Hesselink MK, Schrauwen-Hinderling V, Schrauwen P. Skeletal muscle mitochondria as a target to prevent or treat type 2 diabetes mellitus. Nature reviews Endocrinology. 2016;12(11):633-45.

Hanssen MJ, van der Lans AA, Brans B, Hoeks J, Jardon KM, Schaart G, et al. Short-term Cold Acclimation Recruits Brown Adipose Tissue in Obese Humans. Diabetes. 2016;65(5):1179-89.

Hansen J, Timmers S, Moonen-Kornips E, Duez H, Staels B, Hesselink MK, et al. Synchronized human skeletal myotubes of lean, obese and type 2 diabetic patients maintain circadian oscillation of clock genes. Scientific reports. 2016;6:35047.

Gemmink A, Bosma M, Kuijpers HJ, Hoeks J, Schaart G, van Zandvoort MA, et al. Decoration of intramyocellular lipid droplets with PLIN5 modulates fasting-induced insulin resistance and lipotoxicity in humans. Diabetologia. 2016;59(5):1040-8.

Davies MN, Kjalarsdottir L, Thompson JW, Dubois LG, Stevens RD, Ilkayeva OR, et al. The Acetyl Group Buffering Action of Carnitine Acetyltransferase Offsets Macronutrient-Induced Lysine Acetylation of Mitochondrial Proteins. Cell Rep. 2016;14(2):243-54.

Dahlmans D, Houzelle A, Schrauwen P, Hoeks J. Mitochondrial dynamics, quality control and miRNA regulation in skeletal muscle: implications for obesity and related metabolic disease. Clinical science (London, England : 1979). 2016;130(11):843-52.

Daemen S, van Zandvoort M, Parekh SH, Hesselink MKC. Microscopy tools for the investigation of intracellular lipid storage and dynamics. Molecular metabolism. 2016;5(3):153-63.

Brouwers B, Hesselink MK, Schrauwen P, Schrauwen-Hinderling VB. Effects of exercise training on intrahepatic lipid content in humans. Diabetologia. 2016;59(10):2068-79.

Broeders EP, Vijgen GH, Havekes B, Bouvy ND, Mottaghy FM, Kars M, et al. Thyroid Hormone Activates Brown Adipose Tissue and Increases Non-Shivering Thermogenesis–A Cohort Study in a Group of Thyroid Carcinoma Patients. PloS one. 2016;11(1):e0145049.

2015

Wulan SN, Schrauwen-Hinderling VB, Westerterp KR, Plasqui G. Liver fat accumulation in response to overfeeding with a high-fat diet: a comparison between South Asian and Caucasian men. Nutrition & metabolism. 2015;12:18.

Vosselman MJ, Hoeks J, Brans B, Pallubinsky H, Nascimento EB, van der Lans AA, et al. Low brown adipose tissue activity in endurance-trained compared with lean sedentary men. International journal of obesity (2005). 2015;39(12):1696-702.

van Ewijk PA, Schrauwen-Hinderling VB, Bekkers SC, Glatz JF, Wildberger JE, Kooi ME. MRS: a noninvasive window into cardiac metabolism. NMR Biomed. 2015;28(7):747-66.

van Ewijk PA, Paglialunga S, Kooi ME, Nunes PM, Gemmink A, Slenter J, et al. Effects of high-fat feeding on ectopic fat storage and postprandial lipid metabolism in mouse offspring. Obesity (Silver Spring, Md). 2015;23(11):2242-50.

van de Weijer T, Phielix E, Bilet L, Williams EG, Ropelle ER, Bierwagen A, et al. Evidence for a direct effect of the NAD+ precursor acipimox on muscle mitochondrial function in humans. Diabetes. 2015;64(4):1193-201.

Seiler SE, Koves TR, Gooding JR, Wong, KE, Stevens RD, Ilkayeva OR, Wittman AH, DeBalsi KL, Davies MN, Lindeboom L, Schrauwen P, Schrauwen-Hinderling VB, Muoio DM. Carnitine Acetyltransferase Mitigates Metabolic Inertia and Muscle Fatigue during Exercise. Cell Metab. 2015;22(1):65-76.

Schrauwen P, van Marken Lichtenbelt WD, Spiegelman BM. The future of brown adipose tissues in the treatment of type 2 diabetes. Diabetologia. 2015;58(8):1704-7.

Sarzynski MA, Davidsen PK, Sung YJ, Hesselink MK, Schrauwen P, Rice TK, et al. Genomic and transcriptomic predictors of triglyceride response to regular exercise. British journal of sports medicine. 2015;49(23):1524-31.

Lindeboom L, Nabuurs CI, Hesselink MK, Wildberger JE, Schrauwen P, Schrauwen-Hinderling VB. Proton magnetic resonance spectroscopy reveals increased hepatic lipid content after a single high-fat meal with no additional modulation by added protein. The American journal of clinical nutrition. 2015;101(1):65-71.

Hanssen MJ, Wierts R, Hoeks J, Gemmink A, Brans B, Mottaghy FM, et al. Glucose uptake in human brown adipose tissue is impaired upon fasting-induced insulin resistance. Diabetologia. 2015;58(3):586-95.

Hanssen MJ, Hoeks J, Brans B, van der Lans AA, Schaart G, van den Driessche JJ, et al. Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus. Nature medicine. 2015;21(8):863-5.

Hanssen MJ, Broeders E, Samms RJ, Vosselman MJ, van der Lans AA, Cheng CC, et al. Serum FGF21 levels are associated with brown adipose tissue activity in humans. Scientific reports. 2015;5:10275.

Gnaiger E, Boushel R, Sondergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Diez-Sanchez C, Ara I, Wright-Paradis C, Schrauwen P, Calbet JA, Christiansen M, Helge JW, Slatin B. Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and Caucasians in the arctic winter. Scandinavian journal of medicine & science in sports. 2015;25 Suppl 4:126-34.

Dyck JR, Schrauwen P. Resveratrol: Challenges in translating pre-clinical findings to improved patient outcomes. Biochimica et biophysica acta. 2015;1852(6):1069-70.

Dijk W, Heine M, Vergnes L, Boon MR, Schaart G, Hesselink MK, et al. ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure. eLife. 2015;4.

de Ligt M, Timmers S, Schrauwen P. Resveratrol and obesity: Can resveratrol relieve metabolic disturbances? Biochimica et biophysica acta. 2015;1852(6):1137-44.

Broeders EP, Nascimento EB, Havekes B, Brans B, Roumans KH, Tailleux A, et al. The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity. Cell Metab. 2015;22(3):418-26.

Bilet L, Brouwers B, van Ewijk PA, Hesselink MK, Kooi ME, Schrauwen P, et al. Acute exercise does not decrease liver fat in men with overweight or NAFLD. Scientific reports. 2015;5:9709.

Alssema M, Boers HM, Ceriello A, Kilpatrick ES, Mela DJ, Priebe MG, Schrauwen P, Wolffenbuttel BH, Pfeiffer AF. Diet and glycaemia: the markers and their meaning. A report of the Unilever Nutrition Workshop. The British journal of nutrition. 2015;113(2):239-48.

2014

van Diepen JA, Jansen PA, Ballak DB, Hijmans A, Hooiveld GJ, Rommelaere S, Galland F, Naquet P, Rutjes FP, Mensink RP, Schrauwen P, Tack CJ, Netea MG, Kersten S, Schalkwijk J, Stienstra. PPAR-alpha dependent regulation of vanin-1 mediates hepatic lipid metabolism. Journal of hepatology. 2014;61(2):366-72.

Sparks LM, Bosma M, Brouwers B, van de Weijer T, Bilet L, Schaart G, et al. Reduced incorporation of fatty acids into triacylglycerol in myotubes from obese individuals with type 2 diabetes. Diabetes. 2014;63(5):1583-93.

Schrauwen P, Timmers S. Can resveratrol help to maintain metabolic health? The Proceedings of the Nutrition Society. 2014;73(2):271-7.

Pirinen E, Canto C, Jo YS, Morato L, Zhang H, Menzies KJ, Williams EG, Mouchiroud L, Moullan N, Hagberg C, Li W, Timmers S, Imhof R, Verbeek J, Pujol A, van Loon B, Vicomi C, Zeviani M, Schrauwen P, Sauve AA, Schoonjans K, Auwerx J. Pharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle. Cell Metab. 2014;19(6):1034-41.

Nabben M, van Bree BWJ, Lenaers E, Hoeks J, Hesselink MKC, Schaart G, et al. Lack of UCP3 does not affect skeletal muscle mitochondrial function under lipid-challenged conditions, but leads to sudden cardiac death. Basic research in cardiology. 2014;109(6):447.

Lindeboom L, Nabuurs CI, Hoeks J, Brouwers B, Phielix E, Kooi ME, et al. Long-echo time MR spectroscopy for skeletal muscle acetylcarnitine detection. J Clin Invest. 2014;124(11):4915-25.

Konings E, Timmers S, Boekschoten MV, Goossens GH, Jocken JW, Afman LA, et al. The effects of 30 days resveratrol supplementation on adipose tissue morphology and gene expression patterns in obese men. International journal of obesity (2005). 2014;38(3):470-3.

Jain SS, Paglialunga S, Vigna C, Ludzki A, Herbst EA, Lally JS, et al. High-fat diet-induced mitochondrial biogenesis is regulated by mitochondrial-derived reactive oxygen species activation of CaMKII. Diabetes. 2014;63(6):1907-13.

2013

Vosselman MJ, van Marken Lichtenbelt WD, Schrauwen P. Energy dissipation in brown adipose tissue: from mice to men. Molecular and cellular endocrinology. 2013;379(1-2):43-50.

Vosselman MJ, Brans B, van der Lans AA, Wierts R, van Baak MA, Mottaghy FM, et al. Brown adipose tissue activity after a high-calorie meal in humans. The American journal of clinical nutrition. 2013;98(1):57-64.

Vijgen GH, Sparks LM, Bouvy ND, Schaart G, Hoeks J, van Marken Lichtenbelt WD, et al. Increased oxygen consumption in human adipose tissue from the “brown adipose tissue” region. The Journal of clinical endocrinology and metabolism. 2013;98(7):E1230-4.

Vijgen GH, Bouvy ND, Hoeks J, Wijers S, Schrauwen P, van Marken Lichtenbelt WD. Impaired skeletal muscle mitochondrial function in morbidly obese patients is normalized one year after bariatric surgery. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery. 2013;9(6):936-41.

van Rooijen BD, van der Lans AA, Brans B, Wildberger JE, Mottaghy FM, Schrauwen P, et al. Imaging cold-activated brown adipose tissue using dynamic T2*-weighted magnetic resonance imaging and 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography. Investigative radiology. 2013;48(10):708-14.

van Herpen NA, Sell H, Eckel J, Schrauwen P, Mensink RP. Prolonged fasting and the effects on biomarkers of inflammation and on adipokines in healthy lean men. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2013;45(5):378-82.

van der Lans AA, Hoeks J, Brans B, Vijgen GH, Visser MG, Vosselman MJ, et al. Cold acclimation recruits human brown fat and increases nonshivering thermogenesis. J Clin Invest. 2013;123(8):3395-403.

van de Weijer T, Sparks LM, Phielix E, Meex RC, van Herpen NA, Hesselink MK, et al. Relationships between mitochondrial function and metabolic flexibility in type 2 diabetes mellitus. PloS one. 2013;8(2):e51648.

Timmers S, Hesselink MK, Schrauwen P. Therapeutic potential of resveratrol in obesity and type 2 diabetes: new avenues for health benefits? Annals of the New York Academy of Sciences. 2013;1290:83-9.

Schrauwen P, Timmers S, Hesselink MK. Blocking the entrance to open the gate. Diabetes. 2013;62(3):703-5.

el Azzouzi H, Leptidis S, Dirkx E, Hoeks J, van Bree B, Brand K, et al. The hypoxia-inducible microRNA cluster miR-199a approximately 214 targets myocardial PPARdelta and impairs mitochondrial fatty acid oxidation. Cell Metab. 2013;18(3):341-54.

Bosma M, Sparks LM, Hooiveld GJ, Jorgensen JA, Houten SM, Schrauwen P, et al. Overexpression of PLIN5 in skeletal muscle promotes oxidative gene expression and intramyocellular lipid content without compromising insulin sensitivity. Biochimica et biophysica acta. 2013;1831(4):844-52.

2012

Vosselman MJ, van der Lans AA, Brans B, Wierts R, van Baak MA, Schrauwen P, et al. Systemic beta-adrenergic stimulation of thermogenesis is not accompanied by brown adipose tissue activity in humans. Diabetes. 2012;61(12):3106-13.

Vijgen GH, Bouvy ND, Teule GJ, Brans B, Hoeks J, Schrauwen P, et al. Increase in brown adipose tissue activity after weight loss in morbidly obese subjects. The Journal of clinical endocrinology and metabolism. 2012;97(7):E1229-33.

van de Weijer T, van Ewijk PA, Zandbergen HR, Slenter JM, Kessels AG, Wildberger JE, et al. Geometrical models for cardiac MRI in rodents: comparison of quantification of left ventricular volumes and function by various geometrical models with a full-volume MRI data set in rodents. American journal of physiology Heart and circulatory physiology. 2012;302(3):H709-15.

Phielix E, Meex R, Ouwens DM, Sparks L, Hoeks J, Schaart G, et al. High oxidative capacity due to chronic exercise training attenuates lipid-induced insulin resistance. Diabetes. 2012;61(10):2472-8.

Paglialunga S, van Bree B, Bosma M, Valdecantos MP, Amengual-Cladera E, Jorgensen JA, et al. Targeting of mitochondrial reactive oxygen species production does not avert lipid-induced insulin resistance in muscle tissue from mice. Diabetologia. 2012;55(10):2759-68.

Jans A, van Hees AM, Gjelstad IM, Sparks LM, Tierney AC, Riserus U, et al. Impact of dietary fat quantity and quality on skeletal muscle fatty acid metabolism in subjects with the metabolic syndrome. Metabolism: clinical and experimental. 2012;61(11):1554-65.

Hoeks J, Schrauwen P. Muscle mitochondria and insulin resistance: a human perspective. Trends in endocrinology and metabolism: TEM. 2012;23(9):444-50.

Hoeks J, Mensink M, Hesselink MK, Ekroos K, Schrauwen P. Long- and medium-chain fatty acids induce insulin resistance to a similar extent in humans despite marked differences in muscle fat accumulation. The Journal of clinical endocrinology and metabolism. 2012;97(1):208-16.

Hoeks J, Arany Z, Phielix E, Moonen-Kornips E, Hesselink MK, Schrauwen P. Enhanced lipid-but not carbohydrate-supported mitochondrial respiration in skeletal muscle of PGC-1alpha overexpressing mice. Journal of cellular physiology. 2012;227(3):1026-33.

Bosma M, Minnaard R, Sparks LM, Schaart G, Losen M, de Baets MH, et al. The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria. Histochemistry and cell biology. 2012;137(2):205-16.

Bosma M, Kersten S, Hesselink MK, Schrauwen P. Re-evaluating lipotoxic triggers in skeletal muscle: relating intramyocellular lipid metabolism to insulin sensitivity. Progress in lipid research. 2012;51(1):36-49.

Bosma M, Hesselink MK, Sparks LM, Timmers S, Ferraz MJ, Mattijssen F, et al. Perilipin 2 improves insulin sensitivity in skeletal muscle despite elevated intramuscular lipid levels. Diabetes. 2012;61(11):2679-90.

Beijer E, Schoenmakers J, Vijgen G, Kessels F, Dingemans AM, Schrauwen P, et al. A role of active brown adipose tissue in cancer cachexia? Oncology reviews. 2012;6(1):e11.

2011

Wijers SL, Schrauwen P, van Baak MA, Saris WH, van Marken Lichtenbelt WD. Beta-adrenergic receptor blockade does not inhibit cold-induced thermogenesis in humans: possible involvement of brown adipose tissue. The Journal of clinical endocrinology and metabolism. 2011;96(4):E598-605.

Vijgen GH, Bouvy ND, Teule GJ, Brans B, Schrauwen P, van Marken Lichtenbelt WD. Brown adipose tissue in morbidly obese subjects. PloS one. 2011;6(2):e17247.

van Marken Lichtenbelt WD, Schrauwen P. Implications of nonshivering thermogenesis for energy balance regulation in humans. American journal of physiology Regulatory, integrative and comparative physiology. 2011;301(2):R285-96.

van Herpen NA, Schrauwen-Hinderling VB, Schaart G, Mensink RP, Schrauwen P. Three weeks on a high-fat diet increases intrahepatic lipid accumulation and decreases metabolic flexibility in healthy overweight men. The Journal of clinical endocrinology and metabolism. 2011;96(4):E691-5.

van de Weijer T, Schrauwen-Hinderling VB, Schrauwen P. Lipotoxicity in type 2 diabetic cardiomyopathy. Cardiovascular research. 2011;92(1):10-8.

Timmers S, Konings E, Bilet L, Houtkooper RH, van de Weijer T, Goossens GH, et al. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab. 2011;14(5):612-22.

Timmers S, de Vogel-van den Bosch J, de Wit N, Schaart G, van Beurden D, Hesselink M, et al. Differential effects of saturated versus unsaturated dietary fatty acids on weight gain and myocellular lipid profiles in mice. Nutrition & diabetes. 2011;1:e11.

Schrauwen-Hinderling VB, Meex RC, Hesselink MK, van de Weijer T, Leiner T, Schar M, et al. Cardiac lipid content is unresponsive to a physical activity training intervention in type 2 diabetic patients, despite improved ejection fraction. Cardiovascular diabetology. 2011;10:47.

Nabben M, Shabalina IG, Moonen-Kornips E, van Beurden D, Cannon B, Schrauwen P, et al. Uncoupled respiration, ROS production, acute lipotoxicity and oxidative damage in isolated skeletal muscle mitochondria from UCP3-ablated mice. Biochimica et biophysica acta. 2011;1807(9):1095-105.

Nabben M, Hoeks J, Moonen-Kornips E, van Beurden D, Briede JJ, Hesselink MK, et al. Significance of uncoupling protein 3 in mitochondrial function upon mid- and long-term dietary high-fat exposure. FEBS letters. 2011;585(24):4010-7.

Meex RC, Phielix E, Moonen-Kornips E, Schrauwen P, Hesselink MK. Stimulation of human whole-body energy expenditure by salsalate is fueled by higher lipid oxidation under fasting conditions and by higher oxidative glucose disposal under insulin-stimulated conditions. The Journal of clinical endocrinology and metabolism. 2011;96(5):1415-23.

Jans A, Sparks LM, van Hees AM, Gjelstad IM, Tierney AC, Riserus U, et al. Transcriptional metabolic inflexibility in skeletal muscle among individuals with increasing insulin resistance. Obesity (Silver Spring, Md). 2011;19(11):2158-66.

Hoeks J, Wilde J, Hulshof MF, Berg SA, Schaart G, Dijk KW, et al. High fat diet-induced changes in mouse muscle mitochondrial phospholipids do not impair mitochondrial respiration despite insulin resistance. PloS one. 2011;6(11):e27274.

Brouwers O, Niessen PM, Ferreira I, Miyata T, Scheffer PG, Teerlink T, et al. Overexpression of glyoxalase-I reduces hyperglycemia-induced levels of advanced glycation end products and oxidative stress in diabetic rats. The Journal of biological chemistry. 2011;286(2):1374-80.

Bilet L, van de Weijer T, Hesselink MK, Glatz JF, Lamb HJ, Wildberger J, et al. Exercise-induced modulation of cardiac lipid content in healthy lean young men. Basic research in cardiology. 2011;106(2):307-15.

2010

Schrauwen-Hinderling VB, Hesselink MK, Meex R, van der Made S, Schar M, Lamb H, et al. Improved ejection fraction after exercise training in obesity is accompanied by reduced cardiac lipid content. The Journal of clinical endocrinology and metabolism. 2010;95(4):1932-8.

Schrauwen P, Schrauwen-Hinderling V, Hoeks J, Hesselink MK. Mitochondrial dysfunction and lipotoxicity. Biochimica et biophysica acta. 2010;1801(3):266-71.

Remels AH, Langen RC, Schrauwen P, Schaart G, Schols AM, Gosker HR. Regulation of mitochondrial biogenesis during myogenesis. Molecular and cellular endocrinology. 2010;315(1-2):113-20.

Remels AH, Gosker HR, Schrauwen P, Hommelberg PP, Sliwinski P, Polkey M, et al. TNF-alpha impairs regulation of muscle oxidative phenotype: implications for cachexia? FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2010;24(12):5052-62.

Phielix E, Meex R, Moonen-Kornips E, Hesselink MK, Schrauwen P. Exercise training increases mitochondrial content and ex vivo mitochondrial function similarly in patients with type 2 diabetes and in control individuals. Diabetologia. 2010;53(8):1714-21.

Mencarelli C, Losen M, Hammels C, De Vry J, Hesselink MK, Steinbusch HW, et al. The ceramide transporter and the Goodpasture antigen binding protein: one protein–one function? Journal of neurochemistry. 2010;113(6):1369-86.

Meex RC, Schrauwen-Hinderling VB, Moonen-Kornips E, Schaart G, Mensink M, Phielix E, et al. Restoration of muscle mitochondrial function and metabolic flexibility in type 2 diabetes by exercise training is paralleled by increased myocellular fat storage and improved insulin sensitivity. Diabetes. 2010;59(3):572-9.

Meex RC, Phielix E, Schrauwen-Hinderling VB, Moonen-Kornips E, Schaart G, Schrauwen P, et al. The use of statins potentiates the insulin-sensitizing effect of exercise training in obese males with and without Type 2 diabetes. Clinical science (London, England : 1979). 2010;119(7):293-301.

Lenaers E, De Feyter HM, Hoeks J, Schrauwen P, Schaart G, Nabben M, et al. Adaptations in mitochondrial function parallel, but fail to rescue, the transition to severe hyperglycemia and hyperinsulinemia: a study in Zucker diabetic fatty rats. Obesity (Silver Spring, Md). 2010;18(6):1100-7.

Jocken JW, Moro C, Goossens GH, Hansen D, Mairal A, Hesselink MK, et al. Skeletal muscle lipase content and activity in obesity and type 2 diabetes. The Journal of clinical endocrinology and metabolism. 2010;95(12):5449-53.
161. Hoeks J, van Herpen NA, Mensink M, Moonen-Kornips E, van Beurden D, Hesselink MK, et al. Prolonged fasting identifies skeletal muscle mitochondrial dysfunction as consequence rather than cause of human insulin resistance. Diabetes. 2010;59(9):2117-25.

2009

van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM, Drossaerts JM, Kemerink GJ, Bouvy ND, et al. Cold-activated brown adipose tissue in healthy men. The New England journal of medicine. 2009;360(15):1500-8.

Remels AH, Langen RC, Gosker HR, Russell AP, Spaapen F, Voncken JW, et al. PPARgamma inhibits NF-kappaB-dependent transcriptional activation in skeletal muscle. American journal of physiology Endocrinology and metabolism. 2009;297(1):E174-83.

Minnaard R, Schrauwen P, Schaart G, Jorgensen JA, Lenaers E, Mensink M, et al. Adipocyte differentiation-related protein and OXPAT in rat and human skeletal muscle: involvement in lipid accumulation and type 2 diabetes mellitus. The Journal of clinical endocrinology and metabolism. 2009;94(10):4077-85.

Meex RC, Schrauwen P, Hesselink MK. Modulation of myocellular fat stores: lipid droplet dynamics in health and disease. American journal of physiology Regulatory, integrative and comparative physiology. 2009;297(4):R913-24.

2008

Wijers SL, Schrauwen P, Saris WH, van Marken Lichtenbelt WD. Human skeletal muscle mitochondrial uncoupling is associated with cold induced adaptive thermogenesis. PloS one. 2008;3(3):e1777.

Timmers S, Schrauwen P, de Vogel J. Muscular diacylglycerol metabolism and insulin resistance. Physiology & behavior. 2008;94(2):242-51.

Schrauwen-Hinderling VB, Mensink M, Hesselink MK, Sels JP, Kooi ME, Schrauwen P. The insulin-sensitizing effect of rosiglitazone in type 2 diabetes mellitus patients does not require improved in vivo muscle mitochondrial function. The Journal of clinical endocrinology and metabolism. 2008;93(7):2917-21.

Schrauwen P, Hesselink MK. Reduced tricarboxylic acid cycle flux in type 2 diabetes mellitus? Diabetologia. 2008;51(9):1694-7.

Remels AH, Gosker HR, Schrauwen P, Langen RC, Schols AM. Peroxisome proliferator-activated receptors: a therapeutic target in COPD? The European respiratory journal. 2008;31(3):502-8.

Phielix E, Schrauwen-Hinderling VB, Mensink M, Lenaers E, Meex R, Hoeks J, et al. Lower intrinsic ADP-stimulated mitochondrial respiration underlies in vivo mitochondrial dysfunction in muscle of male type 2 diabetic patients. Diabetes. 2008;57(11):2943-9.

Phielix E, Mensink M. Type 2 diabetes mellitus and skeletal muscle metabolic function. Physiology & behavior. 2008;94(2):252-8.

Nabben M, Hoeks J, Briede JJ, Glatz JF, Moonen-Kornips E, Hesselink MK, et al. The effect of UCP3 overexpression on mitochondrial ROS production in skeletal muscle of young versus aged mice. FEBS letters. 2008;582(30):4147-52.

Nabben M, Hoeks J. Mitochondrial uncoupling protein 3 and its role in cardiac- and skeletal muscle metabolism. Physiology & behavior. 2008;94(2):259-69.

Mensink RP, Plat J, Schrauwen P. Diet and nonalcoholic fatty liver disease. Current opinion in lipidology. 2008;19(1):25-9.

Hoeks J, Briede JJ, de Vogel J, Schaart G, Nabben M, Moonen-Kornips E, et al. Mitochondrial function, content and ROS production in rat skeletal muscle: effect of high-fat feeding. FEBS letters. 2008;582(4):510-6.

den Hoed M, Hesselink MK, van Kranenburg GP, Westerterp KR. Habitual physical activity in daily life correlates positively with markers for mitochondrial capacity. Journal of applied physiology (Bethesda, Md : 1985). 2008;105(2):561-8.

2007

Schrauwen-Hinderling VB, Roden M, Kooi ME, Hesselink MK, Schrauwen P. Muscular mitochondrial dysfunction and type 2 diabetes mellitus. Current opinion in clinical nutrition and metabolic care. 2007;10(6):698-703.

Schrauwen-Hinderling VB, Kooi ME, Hesselink MK, Jeneson JA, Backes WH, van Echteld CJ, et al. Impaired in vivo mitochondrial function but similar intramyocellular lipid content in patients with type 2 diabetes mellitus and BMI-matched control subjects. Diabetologia. 2007;50(1):113-20.

Schrauwen P. High-fat diet, muscular lipotoxicity and insulin resistance. The Proceedings of the Nutrition Society. 2007;66(1):33-41.

Schrauwen P. Physical activity and diabetes: current considerations. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. 2007;32(3):535-6.

Remels AH, Schrauwen P, Broekhuizen R, Willems J, Kersten S, Gosker HR, et al. Peroxisome proliferator-activated receptor expression is reduced in skeletal muscle in COPD. The European respiratory journal. 2007;30(2):245-52.

Mensink M, Hesselink MK, Russell AP, Schaart G, Sels JP, Schrauwen P. Improved skeletal muscle oxidative enzyme activity and restoration of PGC-1 alpha and PPAR beta/delta gene expression upon rosiglitazone treatment in obese patients with type 2 diabetes mellitus. International journal of obesity (2005). 2007;31(8):1302-10.

Mensink M, Hesselink MK, Borghouts LB, Keizer H, Moonen-Kornips E, Schaart G, et al. Skeletal muscle uncoupling protein-3 restores upon intervention in the prediabetic and diabetic state: implications for diabetes pathogenesis? Diabetes, obesity & metabolism. 2007;9(4):594-6.

2006

Schrauwen-Hinderling VB, Hesselink MK, Schrauwen P, Kooi ME. Intramyocellular lipid content in human skeletal muscle. Obesity (Silver Spring, Md). 2006;14(3):357-67.

Schrauwen-Hinderling VB, Hesselink MK, Moonen-Kornips E, Schaart G, Kooi ME, Saris WH, et al. Short-term training is accompanied by a down regulation of ACC2 mRNA in skeletal muscle. International journal of sports medicine. 2006;27(10):786-91.

Schrauwen P, Mensink M, Schaart G, Moonen-Kornips E, Sels JP, Blaak EE, et al. Reduced skeletal muscle uncoupling protein-3 content in prediabetic subjects and type 2 diabetic patients: restoration by rosiglitazone treatment. The Journal of clinical endocrinology and metabolism. 2006;91(4):1520-5.

Schrauwen P, Hoeks J, Hesselink MK. Putative function and physiological relevance of the mitochondrial uncoupling protein-3: involvement in fatty acid metabolism? Progress in lipid research. 2006;45(1):17-41.

Minnaard R, Schrauwen P, Schaart G, Hesselink MK. UCP3 in muscle wasting, a role in modulating lipotoxicity? FEBS letters. 2006;580(22):5172-6.

Joosen AM, Bakker AH, Zorenc AH, Kersten S, Schrauwen P, Westerterp KR. PPARgamma activity in subcutaneous abdominal fat tissue and fat mass gain during short-term overfeeding. International journal of obesity (2005). 2006;30(2):302-7.

Hoeks J, Hesselink MK, Sluiter W, Schaart G, Willems J, Morrisson A, et al. The effect of high-fat feeding on intramuscular lipid and lipid peroxidation levels in UCP3-ablated mice. FEBS letters. 2006;580(5):1371-5.

Hoeks J, Hesselink MK, Schrauwen P. Involvement of UCP3 in mild uncoupling and lipotoxicity. Experimental gerontology. 2006;41(7):658-62.

Hoeks J, Hesselink MK, Russell AP, Mensink M, Saris WH, Mensink RP, et al. Peroxisome proliferator-activated receptor-gamma coactivator-1 and insulin resistance: acute effect of fatty acids. Diabetologia. 2006;49(10):2419-26.

Hesselink MK, Minnaard R, Schrauwen P. Eat the meat or feed the meat: protein turnover in remodeling muscle. Current opinion in clinical nutrition and metabolic care. 2006;9(6):672-6.

Gosker HR, Schrauwen P, Broekhuizen R, Hesselink MK, Moonen-Kornips E, Ward KA, et al. Exercise training restores uncoupling protein-3 content in limb muscles of patients with chronic obstructive pulmonary disease. American journal of physiology Endocrinology and metabolism. 2006;290(5):E976-81.

2005

Schrauwen-Hinderling VB, Kooi ME, Hesselink MK, Moonen-Kornips E, Schaart G, Mustard KJ, et al. Intramyocellular lipid content and molecular adaptations in response to a 1-week high-fat diet. Obesity research. 2005;13(12):2088-94.

Schrauwen P, Russell AP, Moonen-Kornips E, Boon N, Hesselink MK. Effect of 2 weeks of endurance training on uncoupling protein 3 content in untrained human subjects. Acta physiologica Scandinavica. 2005;183(3):273-80.

Schrauwen P, Hesselink MK, Jain M, Cianflone K. Acylation-stimulating protein: effect of acute exercise and endurance training. International journal of obesity (2005). 2005;29(6):632-8.

Roorda BD, Hesselink MK, Schaart G, Moonen-Kornips E, Martinez-Martinez P, Losen M, et al. DGAT1 overexpression in muscle by in vivo DNA electroporation increases intramyocellular lipid content. Journal of lipid research. 2005;46(2):230-6.

Hesselink MK, Schrauwen P. Towards comprehension of the physiological role of UCP3. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2005;37(9):550-4.

Drost MR, Hesselink RP, Oomens CW, van der Vusse GJ. Effects of non-contractile inclusions on mechanical performance of skeletal muscle. Journal of biomechanics. 2005;38(5):1035-43.

DeJong CH, Busquets S, Moses AG, Schrauwen P, Ross JA, Argiles JM, et al. Systemic inflammation correlates with increased expression of skeletal muscle ubiquitin but not uncoupling proteins in cancer cachexia. Oncology reports. 2005;14(1):257-63.

2004

Schrauwen P, Hesselink MK. The role of uncoupling protein 3 in fatty acid metabolism: protection against lipotoxicity? The Proceedings of the Nutrition Society. 2004;63(2):287-92.

Schrauwen P, Hesselink MK. Oxidative capacity, lipotoxicity, and mitochondrial damage in type 2 diabetes. Diabetes. 2004;53(6):1412-7.

Schrauwen P, Hardie DG, Roorda B, Clapham JC, Abuin A, Thomason-Hughes M, et al. Improved glucose homeostasis in mice overexpressing human UCP3: a role for AMP-kinase? International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. 2004;28(6):824-8.

Schaart G, Hesselink RP, Keizer HA, van Kranenburg G, Drost MR, Hesselink MK. A modified PAS stain combined with immunofluorescence for quantitative analyses of glycogen in muscle sections. Histochemistry and cell biology. 2004;122(2):161-9.

Saris WH, Schrauwen P. Substrate oxidation differences between high- and low-intensity exercise are compensated over 24 hours in obese men. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. 2004;28(6):759-65.

Hesselink MK, van Baak MA. Physical activity and health, novel concepts and new targets: report from the 12th Conference of the International Research Group on the Biochemistry of Exercise. The Proceedings of the Nutrition Society. 2004;63(2):189-97.

Hesselink MK, Mensink M, Schrauwen P. Intramyocellular lipids and insulin sensitivity: does size really matter? Obesity research. 2004;12(5):741-2.

2003

van Loon LJ, Schrauwen-Hinderling VB, Koopman R, Wagenmakers AJ, Hesselink MK, Schaart G, et al. Influence of prolonged endurance cycling and recovery diet on intramuscular triglyceride content in trained males. American journal of physiology Endocrinology and metabolism. 2003;285(4):E804-11.

van Loon LJ, Oosterlaar AM, Hartgens F, Hesselink MK, Snow RJ, Wagenmakers AJ. Effects of creatine loading and prolonged creatine supplementation on body composition, fuel selection, sprint and endurance performance in humans. Clinical science (London, England : 1979). 2003;104(2):153-62.

van Loon LJ, Koopman R, Schrauwen P, Stegen J, Wagenmakers AJ. The use of the [1,2-13C]acetate recovery factor in metabolic research. European journal of applied physiology. 2003;89(3-4):377-83.

Schrauwen-Hinderling VB, van Loon LJ, Koopman R, Nicolay K, Saris WH, Kooi ME. Intramyocellular lipid content is increased after exercise in nonexercising human skeletal muscle. Journal of applied physiology (Bethesda, Md : 1985). 2003;95(6):2328-32.

Schrauwen-Hinderling VB, Schrauwen P, Hesselink MK, van Engelshoven JM, Nicolay K, Saris WH, et al. The increase in intramyocellular lipid content is a very early response to training. The Journal of clinical endocrinology and metabolism. 2003;88(4):1610-6.

Schrauwen P, Hoeks J, Schaart G, Kornips E, Binas B, Van De Vusse GJ, et al. Uncoupling protein 3 as a mitochondrial fatty acid anion exporter. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2003;17(15):2272-4.

Schrauwen P, Hesselink M. Uncoupling protein 3 and physical activity: the role of uncoupling protein 3 in energy metabolism revisited. The Proceedings of the Nutrition Society. 2003;62(3):635-43.

Hoeks J, van Baak MA, Hesselink MK, Hul GB, Vidal H, Saris WH, et al. Effect of beta1- and beta2-adrenergic stimulation on energy expenditure, substrate oxidation, and UCP3 expression in humans. American journal of physiology Endocrinology and metabolism. 2003;285(4):E775-82.

Hoeks J, Hesselink MK, van Bilsen M, Schaart G, van der Vusse GJ, Saris WH, et al. Differential response of UCP3 to medium versus long chain triacylglycerols; manifestation of a functional adaptation. FEBS letters. 2003;555(3):631-7.

Hesselink MK, Mensink M, Schrauwen P. Human uncoupling protein-3 and obesity: an update. Obesity research. 2003;11(12):1429-43.

Hesselink MK, Greenhaff PL, Constantin-Teodosiu D, Hultman E, Saris WH, Nieuwlaat R, et al. Increased uncoupling protein 3 content does not affect mitochondrial function in human skeletal muscle in vivo. J Clin Invest. 2003;111(4):479-86.

Gosker HR, Schrauwen P, Hesselink MK, Schaart G, van der Vusse GJ, Wouters EF, et al. Uncoupling protein-3 content is decreased in peripheral skeletal muscle of patients with COPD. The European respiratory journal. 2003;22(1):88-93.

Drost MR, Maenhout M, Willems PJ, Oomens CW, Baaijens FP, Hesselink MK. Spatial and temporal heterogeneity of superficial muscle strain during in situ fixed-end contractions. Journal of biomechanics. 2003;36(7):1055-63.

2002

Westerterp-Plantenga MS, van Marken Lichtenbelt WD, Strobbe H, Schrauwen P. Energy metabolism in humans at a lowered ambient temperature. Eur J Clin Nutr. 2002;56(4):288-96.

van Marken Lichtenbelt WD, Schrauwen P, van De Kerckhove S, Westerterp-Plantenga MS. Individual variation in body temperature and energy expenditure in response to mild cold. American journal of physiology Endocrinology and metabolism. 2002;282(5):E1077-83.

Schrauwen P, Westerterp-Plantenga MS, Kornips E, Schaart G, van Marken Lichtenbelt WD. The effect of mild cold exposure on UCP3 mRNA expression and UCP3 protein content in humans. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. 2002;26(4):450-7.

Schrauwen P, van Aggel-Leijssen DP, Hul G, Wagenmakers AJ, Vidal H, Saris WH, et al. The effect of a 3-month low-intensity endurance training program on fat oxidation and acetyl-CoA carboxylase-2 expression. Diabetes. 2002;51(7):2220-6.

Schrauwen P, Hinderling V, Hesselink MK, Schaart G, Kornips E, Saris WH, et al. Etomoxir-induced increase in UCP3 supports a role of uncoupling protein 3 as a mitochondrial fatty acid anion exporter. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2002;16(12):1688-90.

Schrauwen P, Hesselink MK, Vaartjes I, Kornips E, Saris WH, Giacobino JP, et al. Effect of acute exercise on uncoupling protein 3 is a fat metabolism-mediated effect. American journal of physiology Endocrinology and metabolism. 2002;282(1):E11-7.

Schrauwen P, Hesselink M. UCP2 and UCP3 in muscle controlling body metabolism. The Journal of experimental biology. 2002;205(Pt 15):2275-85.

Schrauwen P. Skeletal muscle uncoupling protein 3 (UCP3): mitochondrial uncoupling protein in search of a function. Current opinion in clinical nutrition and metabolic care. 2002;5(3):265-70.

2001

Schrauwen P, Saris WH, Hesselink MK. An alternative function for human uncoupling protein 3: protection of mitochondria against accumulation of nonesterified fatty acids inside the mitochondrial matrix. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2001;15(13):2497-502.

Schrauwen P, Hoppeler H, Billeter R, Bakker AH, Pendergast DR. Fiber type dependent upregulation of human skeletal muscle UCP2 and UCP3 mRNA expression by high-fat diet. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. 2001;25(4):449-56.

Schrauwen P, Hesselink MK, Blaak EE, Borghouts LB, Schaart G, Saris WH, et al. Uncoupling protein 3 content is decreased in skeletal muscle of patients with type 2 diabetes. Diabetes. 2001;50(12):2870-3.

Koopman R, Schaart G, Hesselink MK. Optimisation of oil red O staining permits combination with immunofluorescence and automated quantification of lipids. Histochemistry and cell biology. 2001;116(1):63-8.

Hesselink MK, Keizer HA, Borghouts LB, Schaart G, Kornips CF, Slieker LJ, et al. Protein expression of UCP3 differs between human type 1, type 2a, and type 2b fibers. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2001;15(6):1071-3.

2000

Schrauwen P, Westerterp KR. The role of high-fat diets and physical activity in the regulation of body weight. The British journal of nutrition. 2000;84(4):417-27.

Schrauwen P, Wagenmakers AJ, van Marken Lichtenbelt WD, Saris WH, Westerterp KR. Increase in fat oxidation on a high-fat diet is accompanied by an increase in triglyceride-derived fatty acid oxidation. Diabetes. 2000;49(4):640-6.

Schrauwen P, Schaart G, Saris WH, Slieker LJ, Glatz JF, Vidal H, et al. The effect of weight reduction on skeletal muscle UCP2 and UCP3 mRNA expression and UCP3 protein content in Type II diabetic subjects. Diabetologia. 2000;43(11):1408-16.

Schrauwen P, Blaak EE, Van Aggel-Leijssen DP, Borghouts LB, Wagenmakers AJ. Determinants of the acetate recovery factor: implications for estimation of [13C]substrate oxidation. Clinical science (London, England : 1979). 2000;98(5):587-92.

1999

Schrauwen P, Xia J, Walder K, Snitker S, Ravussin E. A novel polymorphism in the proximal UCP3 promoter region: effect on skeletal muscle UCP3 mRNA expression and obesity in male non-diabetic Pima Indians. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. 1999;23(12):1242-5.

Schrauwen P, Xia J, Bogardus C, Pratley RE, Ravussin E. Skeletal muscle uncoupling protein 3 expression is a determinant of energy expenditure in Pima Indians. Diabetes. 1999;48(1):146-9.

Schrauwen P, Troost FJ, Xia J, Ravussin E, Saris WH. Skeletal muscle UCP2 and UCP3 expression in trained and untrained male subjects. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. 1999;23(9):966-72.

1998

Schrauwen P, van Aggel-Leijssen DP, van Marken Lichtenbelt WD, van Baak MA, Gijsen AP, Wagenmakers AJ. Validation of the [1,2-13C]acetate recovery factor for correction of [U-13C]palmitate oxidation rates in humans. The Journal of physiology. 1998;513 ( Pt 1):215-23.

Schrauwen P, Lichtenbelt WD, Saris WH, Westerterp KR. Fat balance in obese subjects: role of glycogen stores. The American journal of physiology. 1998;274(6):E1027-33.

1997

Schrauwen P, van Marken Lichtenbelt WD, Westerterp KR, Saris WH. Effect of diet composition on leptin concentration in lean subjects. Metabolism: clinical and experimental. 1997;46(4):420-4.

Schrauwen P, van Marken Lichtenbelt WD, Westerterp KR. Energy balance in a respiration chamber: individual adjustment of energy intake to energy expenditure. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. 1997;21(9):769-74.

Schrauwen P, van Marken Lichtenbelt WD, Saris WH, Westerterp KR. Changes in fat oxidation in response to a high-fat diet. The American journal of clinical nutrition. 1997;66(2):276-82.

Schrauwen P, van Marken Lichtenbelt WD, Saris WH, Westerterp KR. Role of glycogen-lowering exercise in the change of fat oxidation in response to a high-fat diet. The American journal of physiology. 1997;273(3 Pt 1):E623-9.

Schrauwen P, van Marken Lichtenbelt WD, Saris WH, Westerterp KR. The adaptation of nutrient oxidation to nutrient intake on a high-fat diet. Zeitschrift fur Ernahrungswissenschaft. 1997;36(4):306-9.

1995

Schrauwen P, van Baak MA. The effect of beta-adrenergic blockade on non-esterified fatty acid uptake of exercising skeletal muscle during arm cranking. International journal of sports medicine. 1995;16(7):439-44.

Jeukendrup AE, Saris WH, Schrauwen P, Brouns F, Wagenmakers AJ. Metabolic availability of medium-chain triglycerides coingested with carbohydrates during prolonged exercise. Journal of applied physiology (Bethesda, Md : 1985). 1995;79(3):756-62.