Published in Trends in Molecular Medicine this August, is the review by our colleagues on skeletal muscle mitochondrial network dynamics in metabolic disorders and aging. The full article can be found here: https://doi.org/10.1016/j.molmed.2021.07.013 Read the abstract below. With global demographics trending towards an aging population, the numbers of individuals with an age-associated loss...

The article by our colleagues titled "Resveratrol supplementation reduces ACE2 expresssion in human adipose tissue" which will be published in Adipocyte and is in collaboration with the department of Human Biology. Full text can be found here: https://doi.org/10.1080/21623945.2021.1965315 Read the abstract below. Angiotensin converting enzyme-2 (ACE2) is the cell-surface receptor enabling...

This summer, our colleagues published an article in the American Journal of Physiology-Endocrinology and Metabolism with the title: "Post-exercise changes in myocellular lipid droplet characteristics of young lean individuals are affected by circulatory non-esterified fatty acids". Acute exercise affects intramyocellular lipid (IMCL) storage during exercise and recorvery, particularly in type I mu...

Published in Nature Communications by our colleagues is a new article titled: "Impact of aging and exercise on skeletal muscle mitochondrial capacity, energy metabolism, and physical function", examing to what extent physical activity contributes to the decline in mitochondrial function and muscle health during aging. The full article can be found here: https://doi.org/10.1038/s41467-021-24956-...

Published by our group in Molecular Metabolism was the article titled: "Day-night rhythm of skeletal muscle metabolism is disturbed in older, metabolically compromised individuals". It shows that mitochondrial oxidative capacity does not show a day-night rhythm in older, overweight participants with impaired glucose tolerance and insulin sensitivity. The full article can be found here: https://...

The article from our colleague Frouke Vanweert is now online available and will be publische in the International Journal of Obesity with the following title: "The effect of physical activity level and exercise training on the association between plasma branched-chain amino acids and intrahepatic lipid content in participants with obesity". The full article can be found here: https://doi.org/10...

The article by our colleague Niels Connel titled: "NAD+-Precursor Supplementation With L-Tryptophan, Nicotinic Acid, and Nicotinamide Does Not Affect Mitochondrial Function or Skeletal Muscle Function in Physically Compromised Older Adults" has been published in the Journal of Nutrition. Read the full article here: https://doi.org/10.1093/jn/nxab193 Read the abstract below. BACKGROUND: Boos...

The first article of Anna Veelen has now been published in Molecular Metabolism. This review titled: "Type 2 diabetes subgroups and potential medication strategies in relation to effects on insulin resistance and beta-cell function: A step toward personalised diabetes treatment?"  The full review can be found here: https://doi.org/10.1016/j.molmet.2020.101158 Read the abstract below. BACK...

Together with our colleagues of the department of Human Biology, our colleagues Marlies de Ligt and Matthijs Hesselink published the article "The angiotensin II type 1 receptor blocker valsartan in the battle against COVID-19" in the journal Obesity (Silver Spring).  The full article is available here: https://doi.org/10.1002/oby.23221 Read the abstract below. OBJECTIVE: Severe acute resp...

In collaboration with our colleagues in at University of Amsterdam, Jan-Frieder Harmsen has published a new article in  the FASEB Journal and demonstrated that controlled shortterm circadian misalignment distributed the skeletal muscle lipidome, whereas lipid droplet morphology remained unalterd. The full manuscript with the title "Circadian misalignment disturbs the skeletal muscle lipidome in...