Our colleague Anne Gemmink, together with other members of our research group, published an article titled: "Decoration of myocellular lipid droplets with perilipins as a marker for in vivo lipid droplet dynamics: A super-resolution microscopy study in trained athletes and insulin resistant individuals". This article is published in Biochimica et Biophysica Acta - Molecular and Cell Biology of Lip...

The very first article of Froukje Vanweert as first author has been published titled "Elevated plasma branched-chain amino acid levels correlate with type 2 diabetes-related metabolic disturbances". The full article can be found online: https://doi.org/10.1210/clinem/dgaa751 Read the abstract below: CONTEXT: Patients with type 2 diabetes (T2DM) have elevated plasma branched-chain amino acid ...

Last week during the virtual EASD meeting, Yvo op den Kamp presented his work on the effects of 5 weeks of treatment with dapagliflozin, a SGLT2 inhibitor, on energy metabolism in patients with type 2 diabetes. The key messages of this presentation were that dapagliflozin treatment vs placebo resulted in: Unchanged 24-h energy expenditure, while 24-h fatty acid oxidation increased, inducing a...

Now online available is the most recent article by Yvonne Bruls and colleagues titled " L-carnitine infusion does not alleviate lipid-induced insulin resistance and metabolic inflexibility". The full article can be found online: https://doi.org/10.1371/journal.pone.0239506 Read the abstract below: BACKGROUND: Low carnitine status may underlie the development of insulin resistance and metabol...

During the virtual EASD meeting, Yvonne Bruls presented her work on carnitine supplementation in type 2 diabetes patients. The key messages of this presentation were that: Three months carnitine supplementation (2970 mg/day) increased plasma free carnitine availability in type 2 diabetes patients Carnitine supplementation increased resting skeletal muscle acetylcarnitine concentrations and...

Published in Diabetologia online ahead of print is the article of Sabine Daemen and colleagues titled: "Label-free CARS microscopy reveals similar triacylglycerol acyl chain length and saturation in myocellular lipid droplets of athletes and individuals with type 2 diabetes". The full article can be found online: https://doi.org/10.1007/s00125-020-05266-6 Read the abstract below: AIMS/HY...

This recent article of our colleague Emmani titled "Comparative transcriptome analysis of human skeletal muscle in response to cold acclimation and exercise training in human volunteers" is now online available. This article is published in BMC Medical Genomics and the full article can be found here:  https://doi.org/10.1186/s12920-020-00784-z  Read the abstract below: PURPOSE: Cold acclimation ...

The recent article of Emmani has been published in BMC Medical Genomics with the title "Comparative transcriptome analysis of human skeletal muscle in response to cold acclimation and exercise training in human volunteers". The link to this article is: https://doi.org/10.1186/s12920-020-00784-z. Read the abstract below: BACKGROUND:Cold acclimation and exercise training were previously shown ...

Pandi, together with Kim Brouwers, Joachim Wildberger, Vera Schrauwen-Hinderling, and Lucas Lindeboom, published a new article on the 3rd of July on a new MR sequence for 13C-tracking experiments in human liver in Vivo titled: " ". This article is published in Magnetic Resonance in Medicine and the full article can be found here: https://doi.org/10.1002/mrm.28394 Read the abstract below: PUR...

Yes! We are starting up again with our clinical studies. Many projects came to a sudden halt because of all precaution measures regarding COVID-19. Although the start-up is slow, we are happy to be able to get back to our research unit and welcome participants again. Good luck to all our colleagues with getting back into the rhythm of screenings and test days!