Kay Roumans recently received a grant from the Dutch Diabetes Foundation. This grant will enable him to set-up a new MRS measurement, that will be used to determine liver-specific gluconeogenesis. Next, Kay will investigate if gluconeogenesis is increased at night in people with prediabetes and whether lowering it helps to improve metabolic health. The study results can contribute to the developme...

The article from our colleague Froukje Vanweert is now online available and will be published in the Nature Communications with the following title: “A randomized placebo-controlled clinical trial for pharmacological activation of BCAA catabolism in patients with type 2 diabetes”. The full article can be found here: https://doi.org/10.1038/s41467-022-31249-9   Read the abstract below...

In collaboration with Riekelt Houtkooper and Georges Janssens from Amsterdam UMC our colleagues Joris Hoeks and Lotte Grevendonk published their latest research on "healthy aging and muscle function are positively associated with NAD+ abundance in humans" in Nature Aging.  https://www.maastrichtuniversity.nl/news/energy-metabolism-muscles-active-seniors-almost-par-young-people The full artic...

Rodrigo Mancilla successfully defended his thesis today, 10th of February 2022, at 4:00 p.m.. His thesis is called "Novel aspects of exercise training to promote human metabolic health".  

The article from our colleague Frieder Harmsen is now online available and will be published in the Diabetologia with the following title: “The influence of bright and dim light on substrate metabolism, energy expenditure and thermoregulation in insulin-resistant individuals depends on time of day”. The full article can be found here: https://link.springer.com/article/10.1007/s00125-021-05643-9...

Last week during the Annual Dutch Diabetes Research Meeting, Charlotte Andriessen presented her work on the effect of time restricted eating on glucose homeostasis, insulin sensitivity and nocturnal fat oxidation in adults with type 2 diabetes The key messages of this presentation were that: Three weeks of a 10hr daytime TRE effective in improving glucose homeostasis in patients with type ...

Last week during the Annual Dutch Diabetes Research Meeting, Julian Mevenkamp presented his work on the development of a new Phosphorus Magnetic Resonance Technique to detect NAD-metabolites in skeletal muscle. The key messages of this presentation were that: NAD-metabolites can be measured non-invasively by 31P-MRS Acute changes in NAD-metabolite levels can be determined Differences...

Last week during the Annual Dutch Diabetes Research Meeting, Esther Phielix presented on behalf of Froukje Vanweert their work on the effects of lowering BCAA levels in patients with type 2 diabetes using sodium-phenylbutyrate (NaPB). The key messages of this presentation were: 2-week NaPB treatment in patients with type 2 diabetes effectively reduced plasma BCAA levels The reduction of...

Kay Roumans was granted a Junior Fellowship by the Dutch Diabetes Research Foundation. With this, he wants to develop a new MRS technique to measure hepatic gluconeogenesis non-invasively and in real-time. It is possible that people with prediabetes produce more sugars at night, which prevents the body from switching to fat oxidation. This may play a role in the development of type 2 diabetes. Kay...

The article from our colleague Vera de Wit is now online available and will be published in Biomolecules with the following title: “Changes in Cardiac Metabolism in Prediabetes". The full article can be found here: https://doi.org/10.3390/biom11111680 Read the abstract below: In type 2 diabetes mellitus (T2DM), there is an increased prevalence of cardiovascular disease (CVD), even when ...