Published in Diabetes Care by our colleague Yvo op den Kamp and now available online ahead of print is the article called: "Effects of the SGLT2 Inhibitor Dapagliflozin on Energy Metabolism in Patients With Type 2 Diabetes: A Randomized, Double-Blind Crossover Trial". Full article can be found here: https://doi.org/10.2337/dc20-2887 Read the abstract below. OBJECTIVE: SGTL2 inhibitors inc...

Scientists from the Netherlands and Canada are to investigate whether lifestyle changes can help to restore the 24-hour rhythm of people at a high risk of developing type 2 diabetes. The Dutch researchers, including Professor Patrick Schrauwen of Maastricht University, have already concluded that people with a predisposition to type 2 diabetes have a disrupted circadian rhythm, or biological cl...

A recent manuscript published in Nature Communication by our team show that mild cold acclimation for 10 days in patients with type 2 diabetes in which observable, overt shivering was prevented, does not result in improved insulin sensitivity. The full article can be found here: https://doi.org/10.1038/s41467-021-21813-0 ABSTRACT Mild cold acclimation for 10 days has been previously shown to...

An interesting read by our colleague Sten van Beek on "Prolonged β 2-adrenergic agonist treatment improves glucose homeostasis in diet-induced obese UCP1 -/- mice". This manuscript is published in the American Journal of Physiology Metabolism & Endocrinology and full text can be found online: https://doi.org/10.1152/ajpendo.00324.2020  Read the abstract below: Prolonged supplementation...

The thesis defence of Niels Connell can be followed via the following link: https://youtu.be/joKhwHaE7BE

The newest review by Charlotte Andriessen has been published (ahead of print) in the International Journal of Obesity with the title: "The importance of 24-h metabolism in obesity-related metabolic disorders: opportunities for timed interventions". The  review can be found online: https://doi.org/10.1038/s41366-020-00719-9 Read the abstract below: Various metabolic processes in the body osci...

Last week, a new article of Kay Roumans was published online ahead of print: "Liver fat storage pathways: methodologies and dietary effects". The article in Current Opinion in Lipodology can be found here: https://doi.org/10.1097/mol.0000000000000720  Read the abstract below: PURPOSE OF REVIEW: Nonalcoholic fatty liver is the result of an imbalance between lipid storage [from meal, de novo l...

Our colleague Anne Gemmink, together with other members of our research group, published an article titled: "Decoration of myocellular lipid droplets with perilipins as a marker for in vivo lipid droplet dynamics: A super-resolution microscopy study in trained athletes and insulin resistant individuals". This article is published in Biochimica et Biophysica Acta - Molecular and Cell Biology of Lip...

The very first article of Froukje Vanweert as first author has been published titled "Elevated plasma branched-chain amino acid levels correlate with type 2 diabetes-related metabolic disturbances". The full article can be found online: https://doi.org/10.1210/clinem/dgaa751 Read the abstract below: CONTEXT: Patients with type 2 diabetes (T2DM) have elevated plasma branched-chain amino acid ...

Last week during the virtual EASD meeting, Yvo op den Kamp presented his work on the effects of 5 weeks of treatment with dapagliflozin, a SGLT2 inhibitor, on energy metabolism in patients with type 2 diabetes. The key messages of this presentation were that dapagliflozin treatment vs placebo resulted in: Unchanged 24-h energy expenditure, while 24-h fatty acid oxidation increased, inducing a...