NVDO – Assessment of metabolic flexibility upon insulin stimulation and incremental submaximal exercise

During the NVDO meeting, Maaike Bergman presented her work on the assessment of metabolic flexibility upon insulin stimulation and incremental submaximal exercise. Metabolic flexibility is defined as the adaptability of substrate oxidation to substrate availability, which is commonly measured as the change in respiratory exchange ratio. In obese, metabolically compromised subjects, metabolic fl...
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NVDO – Slow activation of oxidative metabolism at the onset of exercise is associated with low CRAT protein activity

Rodrigo Mancilla presented during the NVDO meeting about the slow activation of oxidative metabolism at the onset of exercise and how this is associated with low CRAT protein activity. Metabolically compromised subjects, such as obese and type 2 diabetic patients, exhibit a strong reliance on oxygen-independent pathways (for example PCr hydrolysis) to resynthesize ATP when exercise starts. This...
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NVDO – Sedentary time replaced by standing and walking is as effective in improving peripheral insulin sensitivity compared to exercise training

Carlijn Remie presented on behalf of Kay Roumans about how replacing sedentary time by standing and walking is as effective in improving peripheral insulin sensitivity compared to exercise training. Replacing sitting time with several hours of walking and standing does improve peripheral insulin sensitivity to the same extent as replacing sitting time by 1 hour of vigorous exercise.
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NVDO – Absence of a day-night rhythm in skeletal muscle metabolism of insulin resistant individuals

During the NVDO meeting, Ciarán presented about the absence of a day-night rhythm in skeletal muscle metabolism of insulin-resistant individuals. The key messages of his presentation where that: Insulin resistant individuals have a marked absence of day-night variation in skeletal muscle mitochondrial function Day-Night rhythm of peripheral clock gene expression is disrupted in individuals...
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NVDO – Compromised BCAA metabolism in humans with non-alcoholic fatty liver and/or type 2 diabetes is not affected by a 12-week exercise program

Froukje Vanweert presented during the NVDO with her research on compromised BCAA metabolism in humans with non-alcoholic fatty liver and/or type 2 diabetes. Although the association between systemic BCAA and IHL, exercise training-induced reduction in IHL seemed not to be related to changes in BCAA. To conclude, moderate to high physical activity and exercise training seem not to be effective stra...
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NVDO – Skeletal muscle in humans exhibits a day-night rhythm in lipid droplets and in the muscle lipidome

Jan-Frieder Harmsen presented his data on the day-night rhythm in lipid droplets and in the muscle lipidome found in skeletal muscle in humans. He showed that myocellular lipid content and whole muscle lipid composition vary across the day-night cycle under normal living conditions. Day-night rhythmicity was present in over half of diacylglycerol (DAG) lipid species. Future studies are needed to i...
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