Publication in Nature Communication by our team members

A recent manuscript published in Nature Communication by our team show that mild cold acclimation for 10 days in patients with type 2 diabetes in which observable, overt shivering was prevented, does not result in improved insulin sensitivity. The full article can be found here: https://doi.org/10.1038/s41467-021-21813-0

ABSTRACT

Mild cold acclimation for 10 days has been previously shown to markedly improve insulin sensitivity in patients with type 2 diabetes. Here we show in a single-arm intervention study (Trialregister.nl ID: NL4469/NTR5711) in nine patients with type 2 diabetes that ten days of
mild cold acclimation (16–17 °C) in which observable, overt shivering was prevented, does not result in improved insulin sensitivity, postprandial glucose and lipid metabolism or intrahepatic lipid content and only results in mild effects on overnight fasted fat oxidation, postprandial energy expenditure and aortic augmentation index. The lack of marked metabolic effects in this study is associated with a lack of self-reported shivering and a lack of upregulation of gene expression of muscle activation or muscle contraction pathways in skeletal
muscle and suggests that some form of muscle contraction is needed for beneficial effects of mild cold acclimation.