DMRG day

DMRG day
The Diabetes and Metabolism Research Group spent some time outside of the research labs to fully align with the circadian rhythm in the form of a treasure hunt on and around the Sint Pietersberg and open-air winter barbecue.
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EFSD grant for Jan-Frieder Harmsen

EFSD grant for Jan-Frieder Harmsen
Congratulations to our colleague Jan-Frieder Harmsen who secured a grant of the European Foundation for the Study of Diabetes (E FSD)! The project will focus on circadian rhythm and will build further on the previous day-night rhythm studies performed by our group. These studies revealed that pre-diabetes volunteers lack day-night rhythmicity in mitochondrial function and in 24h substrate m...
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NVDO – Assessment of metabolic flexibility upon insulin stimulation and incremental submaximal exercise

NVDO – Assessment of metabolic flexibility upon insulin stimulation and incremental submaximal exercise
During the NVDO meeting, Maaike Bergman presented her work on the assessment of metabolic flexibility upon insulin stimulation and incremental submaximal exercise. Metabolic flexibility is defined as the adaptability of substrate oxidation to substrate availability, which is commonly measured as the change in respiratory exchange ratio. In obese, metabolically compromised subjects, metabolic fl...
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NVDO – Slow activation of oxidative metabolism at the onset of exercise is associated with low CRAT protein activity

NVDO – Slow activation of oxidative metabolism at the onset of exercise is associated with low CRAT protein activity
Rodrigo Mancilla presented during the NVDO meeting about the slow activation of oxidative metabolism at the onset of exercise and how this is associated with low CRAT protein activity. Metabolically compromised subjects, such as obese and type 2 diabetic patients, exhibit a strong reliance on oxygen-independent pathways (for example PCr hydrolysis) to resynthesize ATP when exercise starts. This...
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NVDO – Sedentary time replaced by standing and walking is as effective in improving peripheral insulin sensitivity compared to exercise training

NVDO – Sedentary time replaced by standing and walking is as effective in improving peripheral insulin sensitivity compared to exercise training
Carlijn Remie presented on behalf of Kay Roumans about how replacing sedentary time by standing and walking is as effective in improving peripheral insulin sensitivity compared to exercise training. Replacing sitting time with several hours of walking and standing does improve peripheral insulin sensitivity to the same extent as replacing sitting time by 1 hour of vigorous exercise.
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NVDO – Absence of a day-night rhythm in skeletal muscle metabolism of insulin resistant individuals

During the NVDO meeting, Ciarán presented about the absence of a day-night rhythm in skeletal muscle metabolism of insulin-resistant individuals. The key messages of his presentation where that: Insulin resistant individuals have a marked absence of day-night variation in skeletal muscle mitochondrial function Day-Night rhythm of peripheral clock gene expression is disrupted in individuals...
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NVDO – Compromised BCAA metabolism in humans with non-alcoholic fatty liver and/or type 2 diabetes is not affected by a 12-week exercise program

NVDO – Compromised BCAA metabolism in humans with non-alcoholic fatty liver and/or type 2 diabetes is not affected by a 12-week exercise program
Froukje Vanweert presented during the NVDO with her research on compromised BCAA metabolism in humans with non-alcoholic fatty liver and/or type 2 diabetes. Although the association between systemic BCAA and IHL, exercise training-induced reduction in IHL seemed not to be related to changes in BCAA. To conclude, moderate to high physical activity and exercise training seem not to be effective stra...
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