Molecular Metabolism recently published DMRG's latest study entitled "Demonstration of a day-night rhythm in human skeletal muscle oxidative capacity". A disturbed day-night rhythm is associated with metabolic perturbations that can lead to obesity and type 2 diabetes mellitus (T2DM). In skeletal muscle, a reduced oxidative capacity is also associated with the development of T2DM. The results of t...

For his translational research on skeletal muscle insulin resistance, mitochondrial function and energy metabolism in the pathogenesis of type 2 diabetes Patrick Schrauwen has been awarded this year’s Minkowski Prize of the European Association for the Study of Diabetes (EASD). It is considered the most important European diabetes research award for young scientists and is endowed with 20,000 euro...

DMRG recently published three new papers. These papers can be found via the links below. Sparks LM, Gemmink A, Phielix E, Bosma M, Schaart G, Moonen-Kornips E, Jörgensen JA, Nascimento EB, Hesselink MK, Schrauwen P, Hoeks J. ANT1-mediated fatty acid-induced uncoupling as a target for improving myocellular insulin sensitivity. Diabetologia, in press, 2016. Lindeboom L, Bruls YM, van Ewijk PA,...

For his research entitled “Demonstration of a Day-Night Rhythm in Skeletal Muscle Mitochondrial Function”, Dirk van Moorsel received the award for best abstract translational endocrinology, during the annual Dutch Endocrine Meeting on January 30th, 2016. For the award; the independent jury scored the quality of the abstract, the presentation and the way of handling questions. The research was a...

DMRG has welcomed 3 new PhD students in the past months: Eva Fechner, started in September 2015. Her project will focus on the influence of dietary interventions on metabolic flexibility. Carlijn Remie, started in October 2015. Carlijn's first study will focus on the effects of 10 day cold acclimation on insulin sensitivity and cardiovascular risk parameters in type 2 diabetic patients. Ka...

Tineke van de Weijer has been awarded the prestigious Junior Research Fellowship 2015 from the Dutch Diabetes Research Foundation for her project entitled "The role of cardiac mitochondrial function and lipid accumulation in the development of cardiac insulin resistance; etiology and treatment strategies". The ambitious project is a collaboration between the Departments of Radiology (J. Wildberger...

Within the System Approaches for Food and Nutrition program, a partnership between the Top Institute for Food and Nutrition (TIFN) and the Netherlands Scientific Organization (NWO), Prof. Patrick Schrauwen and Dr. Joris Hoeks received funding for their project entitled "Nutritional approaches to preserve and improve mitochondrial health and physical function in the elderly". The project (2.2 milli...

Anne's abstract entitled “Change in insulin sensitivity upon a 5-day high-fat diet is related with changes in skeletal muscle PLIN5 protein content in Caucasians, but not in South Asians” was selected for the best abstract session at the Annual Dutch Diabetes Research Meeting (ADDRM) 2015.  Anne presented her results about different responses on insulin sensitivity and PLIN5 protein content betwee...

In a recent publication, DMRG demonstrates that a 2-day intervention with bile acid chenodeoxycholic acid (CDCA) increases brown adipose tissue (BAT) activity together with whole body energy expenditure in healthy humans. Further the involvement of bile acid receptor TGR5 is demonstrated in this human proof-of-concept study. The results have been published in Cell Metabolism.

Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. In a recent publication, DMRG shows that 10 d of cold acclimation (14–15 °C) increased peripheral insulin sensitivity by ~43% in eight type 2 diabetes subjects. Basal skeletal muscle GLUT4 translocation markedly increased, without effects on insulin signaling or AMP-activated protein k...