In a recent publication, DMRG demonstrates that a 2-day intervention with bile acid chenodeoxycholic acid (CDCA) increases brown adipose tissue (BAT) activity together with whole body energy expenditure in healthy humans. Further the involvement of bile acid receptor TGR5 is demonstrated in this human proof-of-concept study. The results have been published in Cell Metabolism.

Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. In a recent publication, DMRG shows that 10 d of cold acclimation (14–15 °C) increased peripheral insulin sensitivity by ~43% in eight type 2 diabetes subjects. Basal skeletal muscle GLUT4 translocation markedly increased, without effects on insulin signaling or AMP-activated protein kinase (AMPK) activation and only a minor increase in BAT glucose uptake. The article was publishe...

For the third time DMRG will participate in the Diabeatit Run to collect money for the Dutch Diabetes Foundation. For this occasion DMRG organizes a benefitconcert on June 4th, 2015 at 20.00 hrs in the Chapel of the congregation called ‘Zusters onder de Bogen’, Sint Servaasklooster 14, 6211 TE Maastricht. A unique place in the heart of the citycenter of Maastricht. The well known semi-professional Maastricht Chamberchoir will perform specific choirmusic from the Barock (Bach, Purcell) and Romant...

Exercise training has been suggested to be able to reduce liver fat content in humans. In a recent publication, we show that this effect is not due to the effect of an acute exercise bout. The paper can be found here

On July 2nd, Lena will publicly defend her dissertation entitled: "Causes and consequences of lipid overload in skeletal muscle, liver and heart" at the aula of Maastricht University, Minderbroedersberg 4-6, Maastricht. Time: 14:00

It is our great pleasure to announce the `5th Diabetes and Metabolism Research Symposium´, a joint initiative from Maastricht University, the German Diabetes Center in Dusseldorf and the University of Lille. The meeting will be held on June 18th and 19th 2015, at Maastricht University Medical Center. The aim of this informal meeting is to present and discuss the ongoing and collaborative research on all aspects of type 2 diabetes, insulin resistance and (energy) metabolism. An important aspec...

Starting April 1st, the Diabetes and Metabolism Research Group welcomes Jakob Wefers as a new PhD student on the project "Circadian Rhythm of Muscle Mitochondrial Metabolism", financed by the Netherlands Organization of Scientific Research (NWO). Jakob did his master study 'human movement sciences' at Maastricht University. For this internship, he performed a study in the lab of Dr. Goodpaster at the Translational Research Institute in Orlando, USA.

The dutch heart foundation has decided to fund our research project ‘energise’ with a total sum of 5 mE. The aim of the project is to investigate if boosting energy expenditure can help to prevent the development of insulin resistance and cardiovascular diseases. The project is a collaboration between the universities of Amsterdam (AMC), Wageningen, Leiden and Maastricht and is lead by Prof. Patrick Schrauwen and Prof. Frits Rosendaal (LUMC). In maastricht, we will specifically focus on skeletal...

The Netherlands Organisation for Health Research and Development (ZonMW) has funded the project Circadian Rhythm of Muscle Mitochondrial Metabolism; the project is a collaboration between the university of Amsterdam (AMC) and Maastricht (MUMC) and is lead by Prof. Andries Kalsbeek and Prof. Patrick Schrauwen.. Because more and more people live a 24h life, disturbances in our normal biological clock are very common. We here investigate if disturbing the biological clock will lead to insulin resis...

Bianca will defend her thesis entitled: "Mitochondria, lipotoxicity and skeletal muscle metabolism: implications for type 2 diabetes mellitus" at the aula of Maastricht University, Minderbroedersberg 4-6, Maastricht. Time: 10.00 am.