The article by Sten van Beek is now available at American Journal of Physiology - Endocrinology and Metabolism and is titled: "Prolonged β2-adrenergic agonist treatment improves glucose homeostasis in diet-induced obese UCP1-/- mice".  Full article can be found here: https://doi.org/10.1152/ajpendo.00324.2020 Read the abstract below. Prolonged supplementation with the β2-agonist clenbuterol improves glucose homeostasis in diabetic rodents, likely via β2-adrenoceptor (β2-AR)-mediated eff...

The thesis defence of Niels Connell can be followed via the following link: https://youtu.be/joKhwHaE7BE

Our colleague Rodrigo Mancilla published an article in Physiological Reports on afternoon vs. morning exercise, titled: "Exercise training elicits superior metabolic effects when performed in the afternoon compared to morning in metabolically compromised humans". Compared to participants who trained in the morning, participants who trained in the afternoon experienced superior beneficial effects of exercise training on peripheral insulin sensitivity, insulin-mediated suppression of adipose tissu...

The newest review by Charlotte Andriessen has been published (ahead of print) in the International Journal of Obesity with the title: "The importance of 24-h metabolism in obesity-related metabolic disorders: opportunities for timed interventions". The  review can be found online: https://doi.org/10.1038/s41366-020-00719-9 Read the abstract below: Various metabolic processes in the body oscillate throughout the natural day, driven by a biological clock. Circadian rhythms are also influence...

Last week, a new article of Kay Roumans was published online ahead of print: "Liver fat storage pathways: methodologies and dietary effects". The article in Current Opinion in Lipodology can be found here: https://doi.org/10.1097/mol.0000000000000720  Read the abstract below: PURPOSE OF REVIEW: Nonalcoholic fatty liver is the result of an imbalance between lipid storage [from meal, de novo lipogenesis (DNL) and fatty acid (FA) uptake] and disposal (oxidation and VLDL output). Knowledge on ...

Our colleague Anne Gemmink, together with other members of our research group, published an article titled: "Decoration of myocellular lipid droplets with perilipins as a marker for in vivo lipid droplet dynamics: A super-resolution microscopy study in trained athletes and insulin resistant individuals". This article is published in Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids and the full article can be found here: https://doi.org/10.1016/j.bbalip.2020.158852 Read the...

The very first article of Froukje Vanweert as first author has been published titled "Elevated plasma branched-chain amino acid levels correlate with type 2 diabetes-related metabolic disturbances". The full article can be found online: https://doi.org/10.1210/clinem/dgaa751 Read the abstract below: CONTEXT: Patients with type 2 diabetes (T2DM) have elevated plasma branched-chain amino acid levels (BCAA). The underlying cause is however not known. Low mitochondrial oxidation of BCAA could ...

Last week during the virtual EASD meeting, Yvo op den Kamp presented his work on the effects of 5 weeks of treatment with dapagliflozin, a SGLT2 inhibitor, on energy metabolism in patients with type 2 diabetes. The key messages of this presentation were that dapagliflozin treatment vs placebo resulted in: Unchanged 24-h energy expenditure, while 24-h fatty acid oxidation increased, inducing a negative fat balance Improved metabolic flexibility as indicated from a larger difference in day...

Now online available is the most recent article by Yvonne Bruls and colleagues titled " L-carnitine infusion does not alleviate lipid-induced insulin resistance and metabolic inflexibility". The full article can be found online: https://doi.org/10.1371/journal.pone.0239506 Read the abstract below: BACKGROUND: Low carnitine status may underlie the development of insulin resistance and metabolic inflexibility. Intravenous lipid infusion elevates plasma free fatty acid (FFA) concentration and...

During the virtual EASD meeting, Yvonne Bruls presented her work on carnitine supplementation in type 2 diabetes patients. The key messages of this presentation were that: Three months carnitine supplementation (2970 mg/day) increased plasma free carnitine availability in type 2 diabetes patients Carnitine supplementation increased resting skeletal muscle acetylcarnitine concentrations and the capacity to form acetylcarnitine with exercise, probably reflecting elevated free carnitine ava...