Kay Roumans was granted a Junior Fellowship by the Dutch Diabetes Research Foundation. With this, he wants to develop a new MRS technique to measure hepatic gluconeogenesis non-invasively and in real-time. It is possible that people with prediabetes produce more sugars at night, which prevents the body from switching to fat oxidation. This may play a role in the development of type 2 diabetes. Kay...

The article from our colleague Vera de Wit is now online available and will be published in Biomolecules with the following title: “Changes in Cardiac Metabolism in Prediabetes". The full article can be found here: https://doi.org/10.3390/biom11111680 Read the abstract below: In type 2 diabetes mellitus (T2DM), there is an increased prevalence of cardiovascular disease (CVD), even when ...

The article from our colleague Froukje Vanweert is now online available and will be published in the Journal of Clinical Endocrinology & Metabolism with the following title: "Elevated Plasma Branched-Chain Amino Acid Levels Correlate With Type 2 Diabetes-Related Metabolic Disturbances". The full article can be found here: https://pubmed.ncbi.nlm.nih.gov/33079174/ Read the abstract below....

The article by Carlijn Remie is now available in Diabetologia with the title: "Sitting less elicits metabolic responses similar to exercise and enhances insulin sensitivity in postmenopausal women". Read the full article here: https://pubmed.ncbi.nlm.nih.gov/33079174/ Read the abstract below. Aims/hypothesis: In our current society sedentary behaviour predominates in most people and is as...

Published in Trends in Molecular Medicine this August, is the review by our colleagues on skeletal muscle mitochondrial network dynamics in metabolic disorders and aging. The full article can be found here: https://doi.org/10.1016/j.molmed.2021.07.013 Read the abstract below. With global demographics trending towards an aging population, the numbers of individuals with an age-associated loss...

The article by our colleagues titled "Resveratrol supplementation reduces ACE2 expresssion in human adipose tissue" which will be published in Adipocyte and is in collaboration with the department of Human Biology. Full text can be found here: https://doi.org/10.1080/21623945.2021.1965315 Read the abstract below. Angiotensin converting enzyme-2 (ACE2) is the cell-surface receptor enabling...

This summer, our colleagues published an article in the American Journal of Physiology-Endocrinology and Metabolism with the title: "Post-exercise changes in myocellular lipid droplet characteristics of young lean individuals are affected by circulatory non-esterified fatty acids". Acute exercise affects intramyocellular lipid (IMCL) storage during exercise and recorvery, particularly in type I mu...

Published in Nature Communications by our colleagues is a new article titled: "Impact of aging and exercise on skeletal muscle mitochondrial capacity, energy metabolism, and physical function", examing to what extent physical activity contributes to the decline in mitochondrial function and muscle health during aging. The full article can be found here: https://doi.org/10.1038/s41467-021-24956-...

Published by our group in Molecular Metabolism was the article titled: "Day-night rhythm of skeletal muscle metabolism is disturbed in older, metabolically compromised individuals". It shows that mitochondrial oxidative capacity does not show a day-night rhythm in older, overweight participants with impaired glucose tolerance and insulin sensitivity. The full article can be found here: https://...

The article from our colleague Frouke Vanweert is now online available and will be publische in the International Journal of Obesity with the following title: "The effect of physical activity level and exercise training on the association between plasma branched-chain amino acids and intrahepatic lipid content in participants with obesity". The full article can be found here: https://doi.org/10...