The article from our colleague Charlotte Andriessen is now online available and will be published in  Diabetologia with the following title: “Three weeks of time-restricted eating improves glucose homeostasis in adults with type 2 diabetes but does not improve insulin sensitivity: a randomised crossover trial”. The full article can be found here: https://doi.org/10.1007/s00125-022-05752-z   Read the abstract below. Aims/hypothesis Time-restricted eating (TRE) is suggested to impr...

The article from our colleague Evi Koene is now online available and will be published in Current opinion in clinical nutrition and metabolic care with the following title: “Novel insights in intestinal and hepatic fructose metabolism: from mice to men". The full article can be found here: https://doi.org/10.3390/biom11111680 Read the abstract below: Purpose of review: The rise in fructose consumption in parallel with the current epidemic of obesity and related cardiometabolic disease...

Kay Roumans recently received a grant from the Dutch Diabetes Foundation. This grant will enable him to set-up a new MRS measurement, that will be used to determine liver-specific gluconeogenesis. Next, Kay will investigate if gluconeogenesis is increased at night in people with prediabetes and whether lowering it helps to improve metabolic health. The study results can contribute to the development of new therapies in the future to prevent type 2 diabetes

The article from our colleague Froukje Vanweert is now online available and will be published in the Nature Communications with the following title: “A randomized placebo-controlled clinical trial for pharmacological activation of BCAA catabolism in patients with type 2 diabetes”. The full article can be found here: https://doi.org/10.1038/s41467-022-31249-9   Read the abstract below. Elevations in plasma branched-chain amino acid (BCAA) levels associate with insulin resistance ...

In collaboration with Riekelt Houtkooper and Georges Janssens from Amsterdam UMC our colleagues Joris Hoeks and Lotte Grevendonk published their latest research on "healthy aging and muscle function are positively associated with NAD+ abundance in humans" in Nature Aging.  https://www.maastrichtuniversity.nl/news/energy-metabolism-muscles-active-seniors-almost-par-young-people The full article can be found here: https://rdcu.be/cHd4X   Read the abstract below. Skeletal muscle...

Rodrigo Mancilla successfully defended his thesis today, 10th of February 2022, at 4:00 p.m.. His thesis is called "Novel aspects of exercise training to promote human metabolic health".  

The article from our colleague Frieder Harmsen is now online available and will be published in the Diabetologia with the following title: “The influence of bright and dim light on substrate metabolism, energy expenditure and thermoregulation in insulin-resistant individuals depends on time of day”. The full article can be found here: https://link.springer.com/article/10.1007/s00125-021-05643-9 Read the abstract below. Aims/hypothesis In our modern society, artificial light is available ...

Last week during the Annual Dutch Diabetes Research Meeting, Charlotte Andriessen presented her work on the effect of time restricted eating on glucose homeostasis, insulin sensitivity and nocturnal fat oxidation in adults with type 2 diabetes The key messages of this presentation were that: Three weeks of a 10hr daytime TRE effective in improving glucose homeostasis in patients with type 2 diabetes Nocturnal substrate oxidation and insulin sensitivity was unaffected by TRE​ TRE in...

Last week during the Annual Dutch Diabetes Research Meeting, Julian Mevenkamp presented his work on the development of a new Phosphorus Magnetic Resonance Technique to detect NAD-metabolites in skeletal muscle. The key messages of this presentation were that: NAD-metabolites can be measured non-invasively by 31P-MRS Acute changes in NAD-metabolite levels can be determined Differences in NAD-metabolite levels between older trained, sedentary and impaired individuals could be measure...

Last week during the Annual Dutch Diabetes Research Meeting, Esther Phielix presented on behalf of Froukje Vanweert their work on the effects of lowering BCAA levels in patients with type 2 diabetes using sodium-phenylbutyrate (NaPB). The key messages of this presentation were: 2-week NaPB treatment in patients with type 2 diabetes effectively reduced plasma BCAA levels The reduction of plasma BCAA levels in these patients was paralleled by a higher peripheral insulin sensitivity and ...