The article from our colleagues Kay Roumans, Anna Veelen and Charlotte Andriessen is now online available and will be published in Obesity with the following title: “A prolonged fast improves overnight substrate oxidation without modulating hepatic glycogen in adults with and without nonalcoholic fatty liver. A randomized crossover trial. The full article can be found here: https://doi.org/10.1002/oby.23676 Read the abstract below. Abstract Objective: Increasing overnight fasting time se...

The review from our colleague Dzhansel Hashim and former colleague Sten van Beek is now online available and will be published in  the International Journal of Obesity with the following title: “Physiological and molecular mechanisms of could-induced improvements in glucose homeostasis in humans beyond brown adipose tissue”. The full article can be found here: https://doi.org/10.1038/s41366-023-01270-z Read the abstract below. Abstract Exposure to low ambient temperatures h...

The article from our colleague Sten van Beek is now online available and will be published in Nature Communications with the following title: “Effect of β2-agonist treatment on insulin-stimulated peripheral glucose disposal in healthy men in a randomised placebo-controlled trial”. The full article can be found here: https://doi.org/10.1038/s41467-023-35798-5 Read the abstract below. Abstract β2-agonist treatment improves skeletal muscle glucose uptake and whole-body glucose homeosta...

The article from our colleague Anna Veelen is now online available and will be published in Metabolism with the following title: “Effects of the sodium-glucose cotransporter 2 inhibitor dapagliflozin on substrate metabolism in prediabetic insulin resistant individuals: A randomized, double-blind crossover trial”. The full article can be found here: https://doi.org/10.1016/j.metabol.2022.155396 Read the abstract below. Abstract Aims/hypothesis: Sodium-glucose cotransporter 2 inh...

The article from our colleague Jan-Frieder Harmsen is now online available and will be published in Cell Reports with the following title: “Divergent remodeling of the skeletal muscle metabolome over 24 h between young, healthy men and older, metabolically compromised men”. The full article can be found here: https://doi.org/10.1016/j.celrep.2022.111786 Read the abstract below. Abstract 24 h whole-body substrate metabolism and the circadian clock within skeletal mus...

Our colleague Froukje Vanweert has been awarded a Kootstra Talent Fellowship. Froukje will focus on the role of branched-chain amino acid (BCAA)  catabolism in type 2 diabetes. The role of BCAA, a specific group of essential amino acids, in the development of insulin resistance and type 2 diabetes has been a topic of renewed interest. Patients with type 2 diabetes feature elevated BCAA levels in plasma, which are linked with metabolic dysfunction. Froukje wants to gain more insight into the link...

The article from our colleague Rodrigo Mancilla is now online available and will be published in  JCI Insight with the following title: “Skeletal muscle mitochondrial inertia associates with carnitine acetyltransferase activity and physical function in humans”. The full article can be found here: https://doi.org/10.1172/jci.insight.163855 Read the abstract below. Background: At the onset of exercise, the speed at which PCr decreases towards a new steady state (PCr on-kinetics), refl...

Sten van Beek successfully defended his thesis today, 23rd of November 2022, at 4:00 p.m.. His thesis is called "Mechanisms of cold-induced improvements in glucose homeostasis".

The article from our colleagues Anne Gemmink and Yvo op den Kamp is now online available and will be published in  Molecular metabolism with the following title: “Effects of SGLT2 inhibitor dapagliflozin in patients with type 2 diabetes on skeletal muscle cellular metabolism”. The full article can be found here: https://doi.org/10.1016/j.molmet.2022.101620   Read the abstract below. Objective: SGLT2 inhibitors increase urinary glucose excretion and have beneficial effects on c...