Froukje Vanweert presented during the NVDO with her research on compromised BCAA metabolism in humans with non-alcoholic fatty liver and/or type 2 diabetes. Although the association between systemic BCAA and IHL, exercise training-induced reduction in IHL seemed not to be related to changes in BCAA. To conclude, moderate to high physical activity and exercise training seem not to be effective strategies to improve BCAA metabolism in metabolically compromised people.

Yvonne Bruls presented during the NVDO meeting with her research on skeletal muscle acetylcarnitine formation, which is compromised in impaired glucose tolerant subjects and type 2 diabetes patients.

Jan-Frieder Harmsen presented his data on the day-night rhythm in lipid droplets and in the muscle lipidome found in skeletal muscle in humans. He showed that myocellular lipid content and whole muscle lipid composition vary across the day-night cycle under normal living conditions. Day-night rhythmicity was present in over half of diacylglycerol (DAG) lipid species. Future studies are needed to investigate whether rhythmicity in DAG is functionally related to insulin sensitivity and how this mi...