SITLESS4 study

How does reducing sitting time improve glucose and lipid metabolism?

Changes in lifestyle are responsible for an important part of the type 2 diabetes epidemic of the last decennia. The western society is characterized by a sedentary lifestyle. Recent studies suggest that sitting time has negative metabolic effects independent of the time spent exercising. It has been shown that replacing sitting with more low intensity physical activity  (such as slowly walking and standing) improved insulin sensitivity and plasma lipid profile more than exercise in healthy young, healthy obese and in type 2 diabetic men and women (SITLESS1 Duvivier et al 2013, SITLESS2 Duvivier et al 2016, SITLESS3 Duvivier et al 2017). With more pronounced effects in women. However, it remains to be determined which underlying mechanisms underlie these changes in glucose and lipid metabolism.

The main objective of the SITLESS4 study is to investigate the underlying mechanisms responsible for insulin sensitivity after 4 days of sitting less compared to sitting and exercise in healthy obese women. The secondary objective is to investigate the effects of sitting less on cardio metabolic parameters.

This project is financed by a grant from CardioVascular Research Netherlands (CVON).
PhD-student: Carlijn Remie