2012

Wu J, Bostrom P, Sparks LM, Ye L, Choi JH, Giang AH, Khandekar M, Virtanen KA, Nuutila P, Schaart G, Huang K, Tu H, van Marken Lichtenbelt WD, Hoeks J, Enerback S, Schrauwen P, Spiegelman BM: Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell, 150, 366-376, 2012.

Vosselman MJ, van der Lans AA, Brans B, Wierts R, van Baak MA, Schrauwen P, van Marken Lichtenbelt WD: Systemic beta-adrenergic stimulation of thermogenesis is not accompanied by brown adipose tissue activity in humans. Diabetes, 61, 3106-3113, 2012.

Vijgen GH, Bouvy ND, Teule GJ, Brans B, Hoeks J, Schrauwen P, van Marken Lichtenbelt WD: Increase in brown adipose tissue activity after weight loss in morbidly obese subjects. Journal of Clinical Endocrinology and Metabolism, 97, E1229-1233, 2012.

van de Weijer T, van Ewijk PA, Zandbergen HR, Slenter JM, Kessels AG, Wildberger JE, Hesselink MK, Schrauwen P, Schrauwen-Hinderling VB, Kooi ME: Geometrical models for cardiac MRI in rodents: comparison of quantification of left ventricular volumes and function by various geometrical models with a full-volume MRI data set in rodents. American Journal of Physiology – Heart and circulatory physiology, 302, H709-715, 2012.

Timmers S, Nabben M, Bosma M, van Bree B, Lenaers E, van Beurden D, Schaart G, Westerterp-Plantenga MS, Langhans W, Hesselink MK, Schrauwen-Hinderling VB, Schrauwen P: Augmenting muscle diacylglycerol and triacylglycerol content by blocking fatty acid oxidation does not impede insulin sensitivity. Proceedings of the National Academy of Sciences of the United States of America, 109, 11711-11716, 2012.

Timmers S, Auwerx J, Schrauwen P: The journey of resveratrol from yeast to human. Aging, 4, 146-158, 2012.

Phielix E, Meex R, Ouwens DM, Sparks L, Hoeks J, Schaart G, Moonen-Kornips E, Hesselink MK, Schrauwen P: High oxidative capacity due to chronic exercise training attenuates lipid-induced insulin resistance. Diabetes, 61, 2472-2478, 2012.

Paglialunga S, van Bree B, Bosma M, Valdecantos MP, Amengual-Cladera E, Jorgensen JA, van Beurden D, den Hartog GJ, Ouwens DM, Briede JJ, Schrauwen P, Hoeks J: Targeting of mitochondrial reactive oxygen species production does not avert lipid-induced insulin resistance in muscle tissue from mice. Diabetologia, 55, 2759-2768, 2012.

Nunes PM, van de Weijer T, Veltien A, Arnts H, Hesselink MK, Glatz JF, Schrauwen P, Tack CJ, Heerschap A: Increased intramyocellular lipids but unaltered in vivo mitochondrial oxidative phosphorylation in skeletal muscle of adipose triglyceride lipase-deficient mice. American journal of Physiology – Endocrinology and metabolism, 303, E71-81, 2012.

Jans A, van Hees AM, Gjelstad IM, Sparks LM, Tierney AC, Riserus U, Drevon CA, Schrauwen P, Roche HM, Blaak EE: Impact of dietary fat quantity and quality on skeletal muscle fatty acid metabolism in subjects with the metabolic syndrome. Metabolism: clinical and experimental, 61, 1554-1565, 2012.

Hoeks J, Schrauwen P: Muscle mitochondria and insulin resistance: a human perspective. Trends in endocrinology and metabolism, 23, 444-450, 2012.

Hoeks J, Mensink M, Hesselink MK, Ekroos K, Schrauwen P: Long- and medium-chain fatty acids induce insulin resistance to a similar extent in humans despite marked differences in muscle fat accumulation. Journal of Clinical Endocrinology and Metabolism, 97, 208-216, 2012.

Hoeks J, Arany Z, Phielix E, Moonen-Kornips E, Hesselink MK, Schrauwen P: Enhanced lipid-but not carbohydrate-supported mitochondrial respiration in skeletal muscle of PGC-1alpha overexpressing mice. Journal of Cellular Physiology, 227, 1026-1033, 2012.

Catoire M, Mensink M, Boekschoten MV, Hangelbroek R, Muller M, Schrauwen P, Kersten S: Pronounced effects of acute endurance exercise on gene expression in resting and exercising human skeletal muscle. PloS one, 7, e51066, 2012.

Bosma M, Minnaard R, Sparks LM, Schaart G, Losen M, de Baets MH, Duimel H, Kersten S, Bickel PE, Schrauwen P, Hesselink MK: The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria. Histochemistry and Cell Biology, 137, 205-216, 2012.

Bosma M, Kersten S, Hesselink MK, Schrauwen P: Re-evaluating lipotoxic triggers in skeletal muscle: relating intramyocellular lipid metabolism to insulin sensitivity. Progress in Lipid Research, 51, 36-49, 2012.

Bosma M, Hesselink MK, Sparks LM, Timmers S, Ferraz MJ, Mattijssen F, van Beurden D, Schaart G, de Baets MH, Verheyen FK, Kersten S, Schrauwen P: Perilipin 2 improves insulin sensitivity in skeletal muscle despite elevated intramuscular lipid levels. Diabetes, 61, 2679-2690, 2012.