2010

Schrauwen, P, Schrauwen-Hinderling, VB, Hoeks, J, Hesselink, MK. Mitochondrial dysfunction and lipotoxicity. Biochim Biophys Acta, 1801(3), 266-271, 2010.

Remels, AHV, Gosker, HR, Schrauwen, P, Hommelberg, P, Sliwinski, P, Polkey, M, Galdiz, J, Wouters, EF, Langen, RC, Schols, AMWJ. TNF-alpha impairs regulation of muscle oxidative phenotype: implications for cachexia in COPD. Faseb J, 24 (12), 5052-5062, 2010.

Hoeks, J, van Herpen, NA, Mensink, M, Moonen-Kornips, E, van Beurden, D, Hesselink, MKC, Schrauwen, P. Prolonged fasting identifies skeletal muscle mitochondrial dysfunction as a consequence rather than cause of human insulin resistance. Diabetes, 59 (9), 2117-2125, 2010.

Berg, SAA van den, Nabben, M, Bijland, S, Voshol, PJ, van Klinken, JB, Havekes, LM, Romijn, JA, Hoeks, J, Hesselink, MK, Schrauwen, P., Willems van Dijk, K. High levels of whole body energy expenditure are associated with a lower coupling of skeletal muscle mitochondria in C57Bl/6 mice. Metabolism, 59 (11), 1612-1618, 2010.

Meex, R, Phielix, E, Schrauwen-Hinderling, VB, Moonen-Kornips, E, Schaart, G, Schrauwen, P, Hesselink, MK. The use of statins potentiates the insulin sensitizing effect of exercise training in obese males with and without type 2 diabetes. Clinical Science, 119, 293-301, 2010.

Vaisy, M, Szlufcik, K, Maris, M, de Bock, K, Hesselink, M, Op ‘t Eijnde, B, Schrauwen, P, Hespel, P. Hyperglycemic diet and training alter insulin sensitivity, intramyocellular lipid content but not UCP3 protein expression in rat skeletal muscle. Int J Mol Med, 25 (6), 905-913, 2010.

Phielix, E, Meex, R, Moonen-Kornips, E, Hesselink, MKC, Schrauwen, P. Exercise training increased mitochondrial content and ex vivo mitochondrial function in male type 2 diabetic patients to similar levels as control subjects. Diabetologia, 53, 1714-1721, 2010.

Shabalina, IG, Hoeks, J, Kramarova, TV, Schrauwen, P, Larsson, N-G, Cannon, B, Nedergaard, J. Cold tolerance of UCP1-ablated mice: a skeletal muscle mitochondria  switch toward lipid oxidation with marked UCP3 up-regulation not associated with increased basal, fatty acid- or ROS-induced uncoupling or enhanced GDP effects, BBA-bioenergetics, 1979 (6-7), 968-980, 2010.

Schrauwen-Hinderling, VB, Hesselink, MK, Meex, R, van der Made, S, Schär, M, Lamb, H, Wildberger, J, Glatz, JFC, Snoep, G, Kooi, ME, Schrauwen, P. Improved ejection fraction after exercise training in obesity is accompanied by reduced cardiac lipid content. JCEM, 95(4), 1932-1988, 2010.

Meex, RCR, Schrauwen-Hinderling, VB, Moonen-Kornips, E, Schaart, G, Mensink, M, Phielix, E, van de Weijer, T, Sels, J-P, Schrauwen, P, Hesselink, MKC. Restoration of muscle mitochondrial function and metabolic flexibility in type 2 diabetes by exercise training is paralleled by increased myocellular fat storage and improved insulin sensitivity. Diabetes, 59(3),572-579, 2010.

Remels, AHV, Langen, RCJ, Schrauwen, P, Schaart, G, Schols, AMWJ, Gosker, HR. Regulation of mitochondrial biogenesis during myogenesis. Mol Cell Endocrinol, 315(1-2), 113-120, 2010.

Timmers, S, de Vogel, J, Towler, MC, Schaart, G, Moonen-Kornips, E, Mensink, RP, Hesselink, MK, Hardie, DG, Schrauwen, P. Prevention of high-fat diet-induced muscular lipid accumulation in rats by dietary alpha lipoic acid is not mediated by skeletal muscle AMPK activation. J Lipid Res, 51(2), 352-359, 2010.

Lenears, E, De Feyter, HM, Hoeks, J, Schrauwen, P, Schaart, G, Nabben, M, Nicolay, K, Prompers, JJ, Hesselink, MKC. Adaptive improvements in mitochondrial function parallel, but fail to rescue, the transition of pre-diabetes into overt type 2 diabetes. Obesity, 18(6), 1100-1107, 2010.