CrAT – Muscle metabolism

– English only –

CrAT: To study the skeletal muscle metabolism during exercise using non-invasive Magnetic Resonance technique.

The purpose of the study is to investigate the ability of the muscle to activate mitochondria during exercise by monitoring a metabolite called phosphocreatine (PCr) through a non-invasive methodology known as Magnetic Resonance Spectroscopy (MRS). We will determine whether this mitochondrial activation event is associated with a protein expressed in muscle named CrAT and the ability of the muscle tissue to obtain oxygen from the circulation. This PCr metabolite, CrAT protein, and oxygen supply to skeletal muscle are important factors for understanding exercise tolerance and muscle fatigue.


  • Sedentary young males
  • 18-40 years old
  • BMI lower than 28 kg/m2
  • Non-vegetarians

Time investment:

  • 2 testdays:
    • Testday 1 = 2 hours
    • Testday 2 = 3 hours


  • Body composition
  • MRI scan
  • Exercise (one-leg extensions for approx. 6 minutes and cycling test of 30 minutes)
  • Muscle biopsy

Compensation: €150,-

Participate in this study?

Contact the involved researcher, Rodrigo Mancilla, by filling in the contact form below.

For more elaborate information about the study, click here for the participant information brochure of CrAT.