Improving metabolic health with a clock

Patrick Schrauwen, together with Dirk Jan Stenver, Frank Scheer, Susanne la Fleur and Andries Kalsbeek published a review about circadian clocks and insulin resistance in Nature Reviews Endocrinology. Read the whole article here: https://doi.org/10.1038/s41574-018-0122-1 

In the picture: Circadian clocks regulate glucose metabolism, insulin sensitivity and insulin secretion.

Key points:

The circadian timing system consists of a central brain clock in the hypothalamic suprachiasmatic nucleus and peripheral clocks in tissues, including the liver, muscle, adipose tissue and pancreas. Misalignment between different components of the circadian timing system and daily rhythms of sleep–wake behaviour and food intake might contribute to the development of insulin resistance. Strategies to improve metabolic health by circadian synchrony include modulating light exposure, modulating rhythmic behaviour and chronotherapy. Circadian molecules are a promising new treatment option for insulin resistance.